Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
03 05 2019
03 05 2019
Historique:
pubmed:
23
4
2019
medline:
17
8
2019
entrez:
23
4
2019
Statut:
ppublish
Résumé
Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.
Identifiants
pubmed: 31008606
doi: 10.1021/acs.orglett.9b01017
doi:
Substances chimiques
Antiviral Agents
0
Sesquiterpenes
0
Spiro Compounds
0
Terpenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng