Serological Markers for Syphilis Among Persons Presenting With Syndromes Associated With Sexually Transmitted Infections: Results From the Zimbabwe STI Etiology Study.
Adolescent
Adult
Biomarkers
/ blood
Female
Genitalia
/ pathology
Humans
Male
Middle Aged
Prevalence
Sentinel Surveillance
Sexually Transmitted Diseases
/ epidemiology
Syphilis
/ blood
Treponema pallidum
Ulcer
/ microbiology
Urban Population
/ statistics & numerical data
Vaginal Discharge
/ microbiology
Young Adult
Zimbabwe
/ epidemiology
Journal
Sexually transmitted diseases
ISSN: 1537-4521
Titre abrégé: Sex Transm Dis
Pays: United States
ID NLM: 7705941
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
pubmed:
23
4
2019
medline:
27
6
2020
entrez:
23
4
2019
Statut:
ppublish
Résumé
Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe. We studied a predominantly urban, regionally diverse group of women and men presenting with genital ulcer disease (GUD), women with vaginal discharge and men with urethral discharge at clinics in Zimbabwe. Syphilis tests included rapid plasma reagin and the Treponema pallidum hemagglutination assay. Among 436 evaluable study participants, 36 (8.3%) tested positive for both rapid plasma reagin and Treponema pallidum hemagglutination assay: women with GUD: 19.2%, men with GUD: 12.6%, women with vaginal discharge: 5.7% and men with urethral discharge: 1.5% (P < 0.0001). Syphilis rates in Zimbabwe are high in sentinel populations, especially men and women with GUD.
Sections du résumé
BACKGROUND
Syphilis prevalence in sub-Saharan Africa appears to be stable or declining but is still the highest globally. Ongoing sentinel surveillance in high-risk populations is necessary to inform management and detect changes in syphilis trends. We assessed serological syphilis markers among persons with sexually transmitted infections in Zimbabwe.
METHODS
We studied a predominantly urban, regionally diverse group of women and men presenting with genital ulcer disease (GUD), women with vaginal discharge and men with urethral discharge at clinics in Zimbabwe. Syphilis tests included rapid plasma reagin and the Treponema pallidum hemagglutination assay.
RESULTS
Among 436 evaluable study participants, 36 (8.3%) tested positive for both rapid plasma reagin and Treponema pallidum hemagglutination assay: women with GUD: 19.2%, men with GUD: 12.6%, women with vaginal discharge: 5.7% and men with urethral discharge: 1.5% (P < 0.0001).
CONCLUSIONS
Syphilis rates in Zimbabwe are high in sentinel populations, especially men and women with GUD.
Identifiants
pubmed: 31008842
doi: 10.1097/OLQ.0000000000001006
pmc: PMC6885999
mid: NIHMS1046912
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-583Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Organisme : PEPFAR
Pays : United States
Références
J Infect Dev Ctries. 2011 Feb 01;5(1):41-7
pubmed: 21330739
Sex Transm Dis. 2013 Dec;40(12):923-8
pubmed: 24220352
Sex Transm Dis. 2012 Nov;39(11):880-5
pubmed: 23064538
Sex Transm Dis. 2019 Mar;46(3):191-195
pubmed: 30363029
MMWR Morb Mortal Wkly Rep. 1999 Sep 10;48(35):773-7
pubmed: 11263546
MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137
pubmed: 26042815
Sex Transm Dis. 2018 Jun;45(6):422-428
pubmed: 29465674
Sex Transm Dis. 2010 Feb;37(2):75-80
pubmed: 19940809
Sex Transm Infect. 2017 Dec;93(8):599-606
pubmed: 28325771
Lancet Glob Health. 2016 Aug;4(8):e525-33
pubmed: 27443780
PLoS One. 2018 Jun 11;13(6):e0198683
pubmed: 29889865
Sex Transm Dis. 2012 Oct;39(10):787-91
pubmed: 23001266
PLoS Med. 2013;10(2):e1001396
pubmed: 23468598
Sex Transm Dis. 2018 Dec;45(12):829-833
pubmed: 29944643
PLoS One. 2015 Dec 08;10(12):e0143304
pubmed: 26646541
Clin Infect Dis. 2005 Nov 1;41(9):1304-12
pubmed: 16206106
Sex Transm Dis. 2018 Jan;45(1):56-60
pubmed: 29240635
MMWR Morb Mortal Wkly Rep. 2002 Sep 27;51(38):853-6
pubmed: 12363336
Sex Transm Dis. 2018 Jan;45(1):61-68
pubmed: 29240636
Sex Health. 2015 Apr;12(2):119-25
pubmed: 25622292