Copper-Promoted C-Se Cross-Coupling of 2-Selenohydantoins with Arylboronic Acids in an Open Flask.
2-selenohydantoins
Chan−Lam−Evans reaction
Se-arylation
boronic acids
cross-coupling
cytotoxicity
in vitro
open flask
selenoureas
Journal
ACS combinatorial science
ISSN: 2156-8944
Titre abrégé: ACS Comb Sci
Pays: United States
ID NLM: 101540531
Informations de publication
Date de publication:
10 06 2019
10 06 2019
Historique:
pubmed:
23
4
2019
medline:
31
12
2019
entrez:
23
4
2019
Statut:
ppublish
Résumé
The modification of Chan-Lam-Evans cross-coupling reaction for the selective Se-arylation of 2-selenohydantoins under base-free mild conditions via aryl boronic acids is described herein. This approach was used to synthesize novel 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones with high yields. The anticancer activity of the final compounds was evaluated in vitro against different cancer cells, and thus, the possibility of 5-arylidene-3-substituted-2-(arylselanyl)-imidazoline-4-ones successful application as cytotoxic agents was demonstrated.
Identifiants
pubmed: 31009196
doi: 10.1021/acscombsci.9b00021
doi:
Substances chimiques
Antineoplastic Agents
0
Boronic Acids
0
Hydantoins
0
Imidazolines
0
Selenium Compounds
0
selenol
0
Copper
789U1901C5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM