Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.
Animal infection model
Plasminogen
Streptococcus pyogenes
Streptokinase
Tissue-type plasminogen activator (tPA)
Urokinase plasminogen activator (uPA)
Journal
Microbes and infection
ISSN: 1769-714X
Titre abrégé: Microbes Infect
Pays: France
ID NLM: 100883508
Informations de publication
Date de publication:
Historique:
received:
27
02
2019
revised:
08
04
2019
accepted:
09
04
2019
pubmed:
23
4
2019
medline:
7
2
2020
entrez:
23
4
2019
Statut:
ppublish
Résumé
Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA
Identifiants
pubmed: 31009808
pii: S1286-4579(19)30051-6
doi: 10.1016/j.micinf.2019.04.004
pmc: PMC7707001
mid: NIHMS1644719
pii:
doi:
Substances chimiques
PLAT protein, human
EC 3.4.21.68
Tissue Plasminogen Activator
EC 3.4.21.68
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
412-417Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL013423
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL013423
Pays : United States
Informations de copyright
Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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