Role of nuclear RNA in regulating chromatin structure and transcription.
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
30
11
2018
revised:
10
03
2019
accepted:
13
03
2019
pubmed:
23
4
2019
medline:
8
2
2020
entrez:
23
4
2019
Statut:
ppublish
Résumé
The importance of three-dimensional chromatin organisation in genome regulation has never been clearer. But in spite of the enormous technological advances to probe chromatin organisation in vivo, there is still a lack of mechanistic understanding of how such an arrangement is achieved. Here we review emerging evidence pointing to an intriguing role of nuclear RNA in shaping large-scale chromatin structure and regulating genome function. We suggest this role may be achieved through the formation of a dynamic nuclear mesh that can exploit ATP-driven processes and phase separation of RNA-binding proteins to tune its assembly and material properties.
Identifiants
pubmed: 31009871
pii: S0955-0674(18)30182-0
doi: 10.1016/j.ceb.2019.03.007
pmc: PMC6694202
pii:
doi:
Substances chimiques
Chromatin
0
RNA, Nuclear
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-125Subventions
Organisme : Medical Research Council
ID : MC_UU_00007/13
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J00913X/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
Genome Biol. 2016 Feb 16;17:28
pubmed: 26883116
Science. 2013 Aug 16;341(6147):1237973
pubmed: 23828888
Biophys J. 2018 May 22;114(10):2262-2270
pubmed: 29628210
Nature. 2017 Jul 13;547(7662):241-245
pubmed: 28636597
Nature. 2015 May 14;521(7551):232-6
pubmed: 25915022
Curr Opin Genet Dev. 2012 Apr;22(2):179-87
pubmed: 22281031
Cell. 2018 Dec 13;175(7):1842-1855.e16
pubmed: 30449618
Phys Rev Lett. 2013 Aug 23;111(8):088101
pubmed: 24010479
Mol Biol Cell. 2000 Mar;11(3):799-805
pubmed: 10712500
Mol Cell. 2015 Oct 15;60(2):208-19
pubmed: 26412307
Genome Res. 2018 Feb;28(2):192-202
pubmed: 29273625
Nucleic Acids Res. 2016 May 5;44(8):3503-12
pubmed: 27060145
Curr Opin Cell Biol. 2015 Jun;34:23-30
pubmed: 25942753
J Cell Sci. 2017 Dec 15;130(24):4213-4224
pubmed: 29122982
Science. 2018 Jul 27;361(6400):
pubmed: 29930091
Mol Cell. 2012 Mar 9;45(5):656-68
pubmed: 22325991
Trends Cell Biol. 2019 Mar;29(3):201-211
pubmed: 30630665
Hum Genet. 2016 Aug;135(8):851-67
pubmed: 27215579
Cell. 2010 Oct 1;143(1):46-58
pubmed: 20887892
Cell. 2018 Nov 29;175(6):1481-1491.e13
pubmed: 30500535
Science. 2018 May 25;360(6391):918-921
pubmed: 29650702
Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):E2636-45
pubmed: 24979791
Nat Rev Genet. 2013 Jun;14(6):390-403
pubmed: 23657480
Nature. 2017 Jul 13;547(7662):236-240
pubmed: 28636604
Science. 2018 Jul 27;361(6400):412-415
pubmed: 29930094
Nucleic Acids Res. 2018 Jan 9;46(1):83-93
pubmed: 29190361
Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Jul;92(1):012317
pubmed: 26274171
Annu Rev Biochem. 1993;62:289-321
pubmed: 8352591
Cell. 2017 Jun 15;169(7):1214-1227.e18
pubmed: 28622508
Nat Struct Mol Biol. 2014 Feb;21(2):198-206
pubmed: 24463464
Cell. 2014 Mar 27;157(1):95-109
pubmed: 24679529
Annu Rev Cell Dev Biol. 2014;30:39-58
pubmed: 25288112
Science. 2018 Jul 27;361(6400):
pubmed: 29930090
Mol Cell. 2016 Jun 2;62(5):657-64
pubmed: 27259198
EMBO J. 1992 Sep;11(9):3431-40
pubmed: 1324173
Cell. 2014 Feb 27;156(5):907-19
pubmed: 24581492
Trends Cell Biol. 2016 Jul;26(7):547-558
pubmed: 27051975
Cell. 2004 Sep 3;118(5):555-66
pubmed: 15339661
Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):E3605-11
pubmed: 24003126
Biophys J. 2017 Mar 28;112(6):1085-1093
pubmed: 28355537
Cell. 2009 Feb 20;136(4):629-41
pubmed: 19239885
Nucleus. 2011 Sep-Oct;2(5):410-24
pubmed: 21983088
Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4334-9
pubmed: 21368180
Cell. 2013 Sep 12;154(6):1190-3
pubmed: 24034243
J Cell Biol. 2019 May 6;218(5):1511-1530
pubmed: 30824489
Cell. 2012 Jun 22;149(7):1447-60
pubmed: 22704655
Cell. 2016 Jun 16;165(7):1686-1697
pubmed: 27212236
Hum Genet. 2017 Jul;136(7):821-834
pubmed: 28393272
Nature. 2016 Jan 21;529(7586):418-22
pubmed: 26760202
Curr Opin Genet Dev. 2016 Apr;37:137-147
pubmed: 27218204
Elife. 2016 Nov 19;5:
pubmed: 27855781