Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis.

Aged Aging / genetics Cohort Studies DNA Methylation Educational Status Epigenesis, Genetic Female Humans Life Style Male Mutation Risk Factors Social Class
biological aging education epigenetic clocks socioeconomic position

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
14 04 2019
Historique:
received: 16 11 2018
accepted: 31 03 2019
entrez: 23 4 2019
pubmed: 23 4 2019
medline: 27 5 2020
Statut: ppublish

Résumé

Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity.

Identifiants

DOI: 10.18632/aging.101900 PMID: 31009935 PMC: PMC6503871
pubmed: 31009935
doi: 10.18632/aging.101900
pii: 101900
pmc: PMC6503871
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2045-2070

Subventions

Organisme : NIEHS NIH HHS
ID : R00 ES023450
Pays : United States
Organisme : Medical Research Council
ID : MR/L01632X/1
Pays : United Kingdom

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Auteurs

Giovanni Fiorito (G)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Equal contribution.

Cathal McCrory (C)

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.
Equal contribution.

Oliver Robinson (O)

MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Equal contribution.

Cristian Carmeli (C)

Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Equal contribution.

Carolina Ochoa-Rosales (C)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Centro de Vida Saludable de la Universidad de Concepción, Concepción, Chile.
Equal contribution.

Yan Zhang (Y)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Equal contribution.

Elena Colicino (E)

Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.
Equal contribution.

Pierre-Antoine Dugué (PA)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Equal contribution.

Fanny Artaud (F)

CESP, Faculté de Médecine - Université Paris-Sud, Faculté de Médecine, UVSQ, Institut National de la Santé et de la Recherche Médicale, -, Université Paris, Saclay, France.
Equal contribution.

Gareth J McKay (GJ)

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
Equal contribution.

Ayoung Jeong (A)

Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Equal contribution.

Pashupati P Mishra (PP)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.
Equal contribution.

Therese H Nøst (TH)

Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
NILU Norwegian Institute for Air Research, The Fram Centre, Tromsø, Norway.
Equal contribution.

Vittorio Krogh (V)

Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy.

Salvatore Panico (S)

Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Carlotta Sacerdote (C)

Piedmont Reference Centre for Epidemiology and Cancer Prevention (CPO Piemonte), Turin, Italy.

Rosario Tumino (R)

Cancer Registry and Histopathology Department, 'Civic - M. P. Arezzo' Hospital, ASP Ragusa, Ragusa, Italy.

Domenico Palli (D)

Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO Toscana), Florence, Italy.

Giuseppe Matullo (G)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Department of Medical Sciences, University of Torino, Torino, Italy.

Simonetta Guarrera (S)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Department of Medical Sciences, University of Torino, Torino, Italy.

Martina Gandini (M)

Environmental Epidemiological Unit, Regional Environmental Protection Agency, Piedmont Region, Torino, Italy.

Murielle Bochud (M)

Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Emmanouil Dermitzakis (E)

Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Taulant Muka (T)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Joel Schwartz (J)

Department of Environmental Health and Department of Epidemiology, Harvard T.H. School of Public Health, Boston, MA 02115, USA.

Pantel S Vokonas (PS)

Department of Epidemiology, Boston University School of Public Health, Boston, MA 02115, USA.

Allan Just (A)

Icahn School of Medicine, Mount Sinai, New York, NY 10029, USA.

Allison M Hodge (AM)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.

Graham G Giles (GG)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.

Melissa C Southey (MC)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Department of Clinical Pathology, The University of Melbourne, Melbourne, Australia.

Mikko A Hurme (MA)

Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland.

Ian Young (I)

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.

Amy Jayne McKnight (AJ)

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.

Sonja Kunze (S)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Melanie Waldenberger (M)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Munich, Germany.

Annette Peters (A)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Cardiovascular Research (DZHK), Munich, Germany.
Ludwig-Maximilians-Universität München, Munich, Germany.

Lars Schwettmann (L)

Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, D-85764, Germany.
Department of Economics, Martin Luther University Halle-Wittenberg, Halle, Germany.
Equal senior researcher.

Eiliv Lund (E)

Department of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
Equal senior researcher.

Andrea Baccarelli (A)

Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Equal senior researcher.

Roger L Milne (RL)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Australia.
Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.
Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia.
Equal senior researcher.

Rose A Kenny (RA)

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.
Equal senior researcher.

Alexis Elbaz (A)

CESP, Faculté de Médecine - Université Paris-Sud, Faculté de Médecine, UVSQ, Institut National de la Santé et de la Recherche Médicale, -, Université Paris, Saclay, France.
Equal senior researcher.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Network Aging Research, University of Heidelberg, Heidelberg, Germany.
Equal senior researcher.

Frank Kee (F)

Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
Equal senior researcher.

Trudy Voortman (T)

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Equal senior researcher.

Nicole Probst-Hensch (N)

Swiss Tropical and Public Health Institute, Basel, Switzerland.
University of Basel, Basel, Switzerland.
Equal senior researcher.

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33520, Finland.
Equal senior researcher.

Paul Elliot (P)

MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Equal senior researcher.

Silvia Stringhini (S)

Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Unit of Population Epidemiology, Primary Care Division, Geneva University Hospitals, Geneva, Switzerland.
Equal senior researcher.

Paolo Vineis (P)

MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
Equal senior researcher.

Silvia Polidoro (S)

Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
Equal senior researcher.
See ACKNOWLEDGMENTS AND FUNDING.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Niveau d'instruction › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Socioeconomic position, lifestyle habits and...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Classe sociale › Socioeconomic position, lifestyle habits and...