Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
20
11
2018
accepted:
03
04
2019
pubmed:
24
4
2019
medline:
17
3
2020
entrez:
24
4
2019
Statut:
ppublish
Résumé
Insulin resistance (IR) is a harbinger of type 2 diabetes (T2D) and partly determined by genetic factors. However, genetically regulated mechanisms of IR remain poorly understood. Using gene expression, genotype, and insulin sensitivity data from the African American Genetics of Metabolism and Expression (AAGMEx) cohort, we performed transcript-wide correlation and expression quantitative trait loci (eQTL) analyses to identify IR-correlated
Identifiants
pubmed: 31010960
pii: db18-1229
doi: 10.2337/db18-1229
pmc: PMC6609988
doi:
Substances chimiques
Enoyl-CoA Hydratase
EC 4.2.1.17
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1508-1522Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK090111
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119962
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118287
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL121172
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118243
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
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