Muscle nonshivering thermogenesis in a feral mammal.
Animals
Animals, Wild
/ genetics
Body Temperature
/ genetics
Cold Temperature
Gene Expression Regulation
Muscle Proteins
/ genetics
Muscle, Skeletal
/ physiology
Proteolipids
/ genetics
Regression Analysis
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/ genetics
Sus scrofa
/ genetics
Thermogenesis
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 04 2019
23 04 2019
Historique:
received:
30
07
2018
accepted:
05
04
2019
entrez:
24
4
2019
pubmed:
24
4
2019
medline:
8
10
2020
Statut:
epublish
Résumé
Muscle nonshivering thermogenesis (NST) was recently suggested to play an important role in thermoregulation of species lacking brown adipose tissue (BAT). The mechanism, which is independent of muscle contractions, produces heat based on the activity of an ATPase pump in the sarcoplasmic reticulum (SERCA1a) and is controlled by the protein sarcolipin. To evaluate whether muscle NST could indeed play an important role in thermoregulation in species lacking BAT, we investigated the thermogenic capacities of newborn wild boar piglets. During cold exposure over the first 5 days of life, total heat production was improved while shivering intensity decreased, indicating an increasing contribution of NST. Sampling skeletal muscle tissue for analyses of SERCA activity as well as gene expression of SERCA1a and sarcolipin, we found an age-related increase in all three variables as well as in body temperature. Hence, the improved thermogenesis during the development of wild boars is not due to shivering but explained by the observed increase in SERCA activity. Our results suggest that muscle NST may be the primary mechanism of heat production during cold stress in large mammals lacking BAT, strengthening the hypothesis that muscle NST has likely played an important role in the evolution of endothermy.
Identifiants
pubmed: 31011179
doi: 10.1038/s41598-019-42756-z
pii: 10.1038/s41598-019-42756-z
pmc: PMC6476883
doi:
Substances chimiques
Muscle Proteins
0
Proteolipids
0
sarcolipin
145018-73-1
Sarcoplasmic Reticulum Calcium-Transporting ATPases
EC 3.6.3.8
Banques de données
figshare
['10.6084/m9.figshare.6839591']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6378Références
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