Dorsolateral prefrontal neurons mediate subjective decisions and their variation in humans.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
25
10
2018
accepted:
08
03
2019
pubmed:
24
4
2019
medline:
6
7
2019
entrez:
24
4
2019
Statut:
ppublish
Résumé
Subjective decisions play a vital role in human behavior because, while often grounded in fact, they are inherently based on personal beliefs that can vary broadly within and between individuals. While these properties set subjective decisions apart from many other sensorimotor processes and are of wide sociological impact, their single-neuronal basis in humans is unknown. Here we find cells in the dorsolateral prefrontal cortex (dlPFC) that reflect variations in the subjective decisions of humans when performing opinion-based tasks. These neurons changed their activities gradually as the participants transitioned between choice options but also reflected their unique point of conversion at equipoise. Focal disruption of the dlPFC, by contrast, diminished gradation between opposing decisions but had little effect on sensory perceptual choices or their motor report. These findings suggest that the human dlPFC plays an important role in subjective decisions and propose a mechanism for mediating their variation during opinion formation.
Identifiants
pubmed: 31011224
doi: 10.1038/s41593-019-0378-3
pii: 10.1038/s41593-019-0378-3
pmc: PMC6535118
mid: NIHMS1523594
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1010-1020Subventions
Organisme : NINDS NIH HHS
ID : K23 NS099380
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091390
Pays : United States
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