Aging with multiple sclerosis: prevalence and profile of cognitive impairment.
Aging
Cognitive impairment
Epidemiology
Multiple sclerosis
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
31
01
2019
accepted:
26
03
2019
pubmed:
24
4
2019
medline:
14
1
2020
entrez:
24
4
2019
Statut:
ppublish
Résumé
The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group. To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients. Patients were consecutively recruited for 6 months. Cognitive performance was assessed through the Brief Repeatable Battery and the Stroop Test. CI was defined as impairment in ≥ 2 cognitive domains. We identified 111 patients older than 55 years (mean age 59.7 years). The prevalence of CI was 77.4%, which was significantly higher than in younger patients (42.8%; p < 0.01). Information processing speed was the most impaired domain (68.8%), followed by verbal learning (49.5%), executive function (47.7%), and visuospatial learning (26.6%). We found no significant differences in the prevalence of impairment in the distinct cognitive domains between older and younger patients with CI. Depression and fatigue were not associated with increased CI among patients in the older age group (p > 0.70). There is a remarkably high frequency of CI in older patients with MS. The similar profile of CI between older and younger patients suggests that CI is mostly directly related to MS itself and not to comorbid age-related disorders.
Sections du résumé
BACKGROUND
BACKGROUND
The increase in life expectancy of patients with multiple sclerosis (MS) requires a better knowledge of disease features in the older patients group.
OBJECTIVE
OBJECTIVE
To describe the prevalence and profile of cognitive impairment (CI) in older patients with MS and perform a comparison with younger patients.
METHODS
METHODS
Patients were consecutively recruited for 6 months. Cognitive performance was assessed through the Brief Repeatable Battery and the Stroop Test. CI was defined as impairment in ≥ 2 cognitive domains.
RESULTS
RESULTS
We identified 111 patients older than 55 years (mean age 59.7 years). The prevalence of CI was 77.4%, which was significantly higher than in younger patients (42.8%; p < 0.01). Information processing speed was the most impaired domain (68.8%), followed by verbal learning (49.5%), executive function (47.7%), and visuospatial learning (26.6%). We found no significant differences in the prevalence of impairment in the distinct cognitive domains between older and younger patients with CI. Depression and fatigue were not associated with increased CI among patients in the older age group (p > 0.70).
CONCLUSION
CONCLUSIONS
There is a remarkably high frequency of CI in older patients with MS. The similar profile of CI between older and younger patients suggests that CI is mostly directly related to MS itself and not to comorbid age-related disorders.
Identifiants
pubmed: 31011932
doi: 10.1007/s10072-019-03875-7
pii: 10.1007/s10072-019-03875-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1651-1657Commentaires et corrections
Type : ErratumIn
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