Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis.
CRISPR-Cas9
cyclin-dependent kinase-5 (CDK5)
migration
phosphorylation
proliferation
upstream stimulatory factor 2 (USF2)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Apr 2019
12 Apr 2019
Historique:
received:
10
02
2019
revised:
30
03
2019
accepted:
08
04
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
epublish
Résumé
The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells.
Identifiants
pubmed: 31013770
pii: cancers11040523
doi: 10.3390/cancers11040523
pmc: PMC6521020
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Suomalainen Tiedeakatemia
ID : SA296027
Organisme : Jane ja Aatos Erkon Säätiö
ID : 2015
Organisme : Syöpäsäätiö
ID : 2018
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