Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota.
cancer
cytotoxic T-lymphocytes
dendritic cells
gut microbiota
immune checkpoint inhibitor therapy
Journal
Integrative cancer therapies
ISSN: 1552-695X
Titre abrégé: Integr Cancer Ther
Pays: United States
ID NLM: 101128834
Informations de publication
Date de publication:
Historique:
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.
Identifiants
pubmed: 31014119
doi: 10.1177/1534735419846379
pmc: PMC6482659
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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