Transcription elements AREB6 and miR-34a affect apoptosis of PAMs by regulating the expression of SS2-related gene PPP1R11.
Animals
Apoptosis
/ genetics
Binding Sites
Down-Regulation
/ genetics
Macrophages, Alveolar
/ metabolism
MicroRNAs
/ genetics
Promoter Regions, Genetic
Protein Binding
Streptococcus suis
/ metabolism
Swine
Transfection
Ubiquitin-Protein Ligases
/ genetics
Up-Regulation
/ genetics
Zinc Finger E-box-Binding Homeobox 1
/ genetics
None
AREB6
Porcine alveolar macrophage
apoptosis
miR-34a
Journal
Cell cycle (Georgetown, Tex.)
ISSN: 1551-4005
Titre abrégé: Cell Cycle
Pays: United States
ID NLM: 101137841
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
25
4
2019
medline:
28
5
2020
entrez:
25
4
2019
Statut:
ppublish
Résumé
In our previous work, gene PPP1R11 (protein phosphatase 1 regulatory subunit 11) was significantly expressed in pigs after Streptococcus suis 2 (SS2) challenged. This study firstly confirmed that SS2 induced significant expression of PPP1R11 gene in porcine alveolar macrophage (PAM) cells, and apoptosis of PAM cells were observed. After that, the core promoter of porcine PPP1R11 was identified and its transcription factor AREB6 which significantly regulated PPP1R11. We also characterized that the PPP1R11 gene is a target of miR-34a. Further, we found that PPP1R11 helped to inhibit apoptosis of PAM cells under SS2 infecting, through transcription factor AREB6 was negatively correlated with apoptosis whereas miR-34a was positively correlated. Those findings provide a functional connection among the transcription factor AREB6, miR-34a, PPP1R11 gene and apoptosis of PAM cells in the pathogenesis of the SS2 infection.
Identifiants
pubmed: 31014175
doi: 10.1080/15384101.2019.1610241
pmc: PMC6527289
doi:
Substances chimiques
MicroRNAs
0
Zinc Finger E-box-Binding Homeobox 1
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1033-1044Références
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