Immune privilege in corneal transplantation.

Corneal Transplantation Graft Survival / immunology Humans Immune Privilege / physiology Immune Tolerance / physiology Lymphangiogenesis / physiology T-Lymphocytes, Regulatory / immunology
ACAID Aqueous humor Corneal transplantation Costimulatory molecules Immune checkpoints Immune privilege Lymph-angiogenesis Neuro-immune crosstalk Regulatory T cells

Journal

Progress in retinal and eye research
ISSN: 1873-1635
Titre abrégé: Prog Retin Eye Res
Pays: England
ID NLM: 9431859

Informations de publication

Date de publication:
09 2019
Historique:
received: 31 01 2019
revised: 14 04 2019
accepted: 16 04 2019
pubmed: 25 4 2019
medline: 5 3 2020
entrez: 25 4 2019
Statut: ppublish

Résumé

Corneal transplantation is the most successful solid organ transplantation performed in humans. The extraordinary success of orthotopic corneal allografts, in both humans and experimental animals, is related to the phenomenon of "immune privilege". Inflammation is self-regulated to preserve ocular functions because the eye has immune privilege. At present, three major mechanisms are considered to provide immune privilege in corneal transplantation: 1) anatomical, cellular, and molecular barriers in the cornea; 2) tolerance related to anterior chamber-associated immune deviation and regulatory T cells; and 3) an immunosuppressive intraocular microenvironment. This review describes the mechanisms of immune privilege that have been elucidated from animal models of ocular inflammation, especially those involving corneal transplantation, and its relevance for the clinic. An update on molecular, cellular, and neural interactions in local and systemic immune regulation is provided. Therapeutic strategies for restoring immune privilege are also discussed.

Identifiants

DOI: 10.1016/j.preteyeres.2019.04.002 PMID: 31014973
pubmed: 31014973
pii: S1350-9462(19)30001-1
doi: 10.1016/j.preteyeres.2019.04.002
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100758

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Junko Hori (J)

Department of Ophthalmology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, 113-8603, Japan; Department of Ophthalmology, Nippon Medical School, Tama-Nagayama Hospital, 1-7-1 Nagayama, Tama, Tokyo, 206-8512, Japan. Electronic address: jhori@nms.ac.jp.

Takefumi Yamaguchi (T)

Department of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-shi, Chiba, 272-8513, Japan; Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Hiroshi Keino (H)

Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.

Pedram Hamrah (P)

Center for Translational Ocular Immunology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, 800 Washington St, Boston, MA, 02111, USA; Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Tufts University, 800 Washington St, Boston, MA, 02111, USA.

Kazuichi Maruyama (K)

Department of Innovative Visual Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.

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Classifications MeSH

questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation de tissu › Transplantation de cornée › Immune privilege in corneal transplantation.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Immune privilege in corneal transplantation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immune privilege in corneal transplantation.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Privilège immun › Immune privilege in corneal transplantation.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Immune privilege in corneal transplantation.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Lymphangiogenèse › Immune privilege in corneal transplantation.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Immune privilege in corneal transplantation.