Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice.

Age Factors Animals Behavior, Animal Biomarkers Cerebrovascular Circulation Cognitive Dysfunction / drug therapy Dietary Supplements Endothelium, Vascular / metabolism Humans Male Maze Learning / drug effects Mice Mitochondria / metabolism Neurovascular Coupling Nicotinamide Mononucleotide / administration & dosage Nitric Oxide / metabolism Oxidative Stress / drug effects RNA, Small Interfering / genetics Reactive Oxygen Species / metabolism
Endothelial dysfunction Functional hyperemia Microcirculation Oxidative stress ROS

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
06 2019
Historique:
received: 22 02 2019
revised: 02 04 2019
accepted: 07 04 2019
pubmed: 25 4 2019
medline: 27 2 2020
entrez: 25 4 2019
Statut: ppublish

Résumé

Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) has an essential role in maintenance of healthy cognitive function. In aging increased oxidative stress and cerebromicrovascular endothelial dysfunction impair NVC, contributing to cognitive decline. There is increasing evidence showing that a decrease in NAD

Identifiants

DOI: 10.1016/j.redox.2019.101192 PMID: 31015147 PMC: PMC6477631
pubmed: 31015147
pii: S2213-2317(19)30240-X
doi: 10.1016/j.redox.2019.101192
pmc: PMC6477631
pii:
doi:

Substances chimiques

Biomarkers 0
RNA, Small Interfering 0
Reactive Oxygen Species 0
Nicotinamide Mononucleotide 1094-61-7
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101192

Subventions

Organisme : NIA NIH HHS
ID : R01 AG038747
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : NIA NIH HHS
ID : DP1 AG058605
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK100263
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG019719
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS056218
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK098656
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG052363
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE027490
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047879
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG050911
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG028730
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132553
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043483
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

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Auteurs

Stefano Tarantini (S)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Marta Noa Valcarcel-Ares (MN)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Peter Toth (P)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neurosurgery, Medical School, University of Pecs, Hungary.

Andriy Yabluchanskiy (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Zsuzsanna Tucsek (Z)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Tamas Kiss (T)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Peter Hertelendy (P)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Michael Kinter (M)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA.

Praveen Ballabh (P)

Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, USA.

Zoltán Süle (Z)

Department of Anatomy, University of Szeged, Szeged, Hungary.

Eszter Farkas (E)

Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.

Joseph A Baur (JA)

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

David A Sinclair (DA)

Department of Genetics, Harvard Medical School, Boston, USA.

Anna Csiszar (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.

Zoltan Ungvari (Z)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging/Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; Department of Public Health, Semmelweis University, Budapest, Hungary; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: zoltan-ungvari@ouhsc.edu.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Facteurs âges › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Eucaryotes › Animaux › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Apprentissage du labyrinthe › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation cérébrovasculaire › Couplage neurovasculaire › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nicotinamide mononucléotide › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › Petit ARN interférent › Nicotinamide mononucleotide (NMN)...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Nicotinamide mononucleotide (NMN)...