StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis.
Adaptor Proteins, Vesicular Transport
/ genetics
Animals
CHO Cells
Cell Membrane
/ metabolism
Cells, Cultured
Cholesterol
/ metabolism
Cricetulus
Endoplasmic Reticulum
/ metabolism
Female
Homeostasis
/ genetics
Immunoblotting
Lipid Metabolism
/ genetics
Macrophages, Peritoneal
/ metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Fluorescence
RNA, Messenger
Triglycerides
/ metabolism
Niemann-Pick C
cholesterol trafficking
endoplasmic reticulum
fatty liver
fluorescence
macrophages
steroidogenic acute regulatory protein-related lipid transfer proteins
steroidogenic acute regulatory-related lipid transfer domain 5
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
20
12
2018
revised:
08
04
2019
pubmed:
25
4
2019
medline:
14
7
2020
entrez:
25
4
2019
Statut:
ppublish
Résumé
How plasma membrane (PM) cholesterol is controlled is poorly understood. Ablation of the gene encoding the ER stress steroidogenic acute regulatory-related lipid transfer domain (StarD)5 leads to a decrease in PM cholesterol content, a decrease in cholesterol efflux, and an increase in intracellular neutral lipid accumulation in macrophages, the major cell type that expresses StarD5. ER stress increases StarD5 expression in mouse hepatocytes, which results in an increase in accessible PM cholesterol in WT but not in StarD5
Identifiants
pubmed: 31015253
pii: S0022-2275(20)32249-5
doi: 10.1194/jlr.M091967
pmc: PMC6547630
doi:
Substances chimiques
Adaptor Proteins, Vesicular Transport
0
RNA, Messenger
0
Stard5 protein, mouse
0
Triglycerides
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1087-1098Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR002649
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000058
Pays : United States
Organisme : NIGMS NIH HHS
ID : P50 GM076516
Pays : United States
Organisme : BLRD VA
ID : I01 BX000197
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103540
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016059
Pays : United States
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