Pten controls B-cell responsiveness and germinal center reaction by regulating the expression of IgD BCR.
Animals
B-Lymphocytes
/ physiology
Cells, Cultured
Forkhead Box Protein O1
/ physiology
Gene Expression Regulation
/ immunology
Germinal Center
/ metabolism
Immunoglobulin D
/ genetics
Mice
Mice, Transgenic
PTEN Phosphohydrolase
/ genetics
Receptors, Antigen, B-Cell
/ genetics
Signal Transduction
/ genetics
B‐cell differentiation
FoxO1
Pten
immune response
tolerance
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
03 06 2019
03 06 2019
Historique:
received:
12
07
2018
revised:
22
03
2019
accepted:
25
03
2019
pubmed:
25
4
2019
medline:
8
1
2020
entrez:
25
4
2019
Statut:
ppublish
Résumé
In contrast to other B-cell antigen receptor (BCR) classes, the function of IgD BCR on mature B cells remains largely elusive as mature B cells co-express IgM, which is sufficient for development, survival, and activation of B cells. Here, we show that IgD expression is regulated by the forkhead box transcription factor FoxO1, thereby shifting the responsiveness of mature B cells towards recognition of multivalent antigen. FoxO1 is repressed by phosphoinositide 3-kinase (PI3K) signaling and requires the lipid phosphatase Pten for its activation. Consequently, Pten-deficient B cells expressing knock-ins for BCR
Identifiants
pubmed: 31015337
pii: embj.2018100249
doi: 10.15252/embj.2018100249
pmc: PMC6545559
pii:
doi:
Substances chimiques
Forkhead Box Protein O1
0
Foxo1 protein, mouse
0
Immunoglobulin D
0
Receptors, Antigen, B-Cell
0
PTEN Phosphohydrolase
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 694992
Pays : International
Informations de copyright
© 2019 The Authors. Published under the terms of the CC BY 4.0 license.
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