Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.

Adolescent Adult Birth Weight / genetics Body Mass Index Child CpG Islands DNA / genetics DNA Methylation Epigenesis, Genetic Female Fetal Development / genetics Fetus Folic Acid / blood Genome, Human Genome-Wide Association Study Humans Infant, Newborn Male Pregnancy Prenatal Exposure Delayed Effects / blood Smoking / adverse effects

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
23 04 2019
Historique:
received: 30 04 2018
accepted: 18 02 2019
entrez: 25 4 2019
pubmed: 25 4 2019
medline: 9 5 2019
Statut: epublish

Résumé

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P

Identifiants

DOI: 10.1038/s41467-019-09671-3 PMID: 31015461 PMC: PMC6478731
pubmed: 31015461
doi: 10.1038/s41467-019-09671-3
pii: 10.1038/s41467-019-09671-3
pmc: PMC6478731
doi:

Substances chimiques

DNA 9007-49-2
Folic Acid 935E97BOY8

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1893

Subventions

Organisme : Medical Research Council
ID : MC_U123292701
Pays : United Kingdom
Organisme : NIH HHS
ID : UH3 OD023275
Pays : United States
Organisme : NIMHD NIH HHS
ID : R01 MD013299
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028522
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK085173
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022223
Pays : United States
Organisme : Medical Research Council
ID : MR/P012019/1
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R00 ES023450
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI091905
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028507
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00026/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/M01424X/1
Pays : United Kingdom
Organisme : NIH HHS
ID : UG3 OD023356
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028226
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U123292700
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R01 ES021369
Pays : United States
Organisme : Medical Research Council
ID : MR/S003886/1
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R01 ES013744
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025574
Pays : United States
Organisme : NIEHS NIH HHS
ID : R24 ES028531
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R01 ES025531
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL132825
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022934
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States

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Auteurs

Leanne K Küpers (LK)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.
Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.

Claire Monnereau (C)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Gemma C Sharp (GC)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
School of Oral and Dental Sciences, University of Bristol, Bristol, UK.
ORCID: 0000-0003-2906-4035

Paul Yousefi (P)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Lucas A Salas (LA)

Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
ISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
ORCID: 0000-0002-2279-4097

Akram Ghantous (A)

Epigenetics Group, International Agency for Research on Cancer, Lyon, France.

Christian M Page (CM)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Oslo Centre for Biostatisitcs and Epidemology, Oslo University Hospital, Oslo, Norway.

Sarah E Reese (SE)

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.

Allen J Wilcox (AJ)

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.

Darina Czamara (D)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
ORCID: 0000-0001-7381-904X

Anne P Starling (AP)

Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Alexei Novoloaca (A)

Epigenetics Group, International Agency for Research on Cancer, Lyon, France.

Samantha Lent (S)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Ritu Roy (R)

HDF Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Computational Biology and Informatics, UCSF, San Francisco, CA, USA.

Cathrine Hoyo (C)

Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.

Carrie V Breton (CV)

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089, USA.

Catherine Allard (C)

Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.
ORCID: 0000-0002-8829-4984

Allan C Just (AC)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Kelly M Bakulski (KM)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-9605-6337

John W Holloway (JW)

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
ORCID: 0000-0001-9998-0464

Todd M Everson (TM)

Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.

Cheng-Jian Xu (CJ)

University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.
University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
ORCID: 0000-0003-1586-4672

Rae-Chi Huang (RC)

Telethon Kids Institute, University of Western Australia, Perth, Australia.

Diana A van der Plaat (DA)

University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

Matthias Wielscher (M)

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.

Simon Kebede Merid (SK)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Vilhelmina Ullemar (V)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Faisal I Rezwan (FI)

Human Development and Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
ORCID: 0000-0001-9921-222X

Jari Lahti (J)

Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland.
Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4310-5297

Jenny van Dongen (J)

Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
ORCID: 0000-0003-2063-8741

Sabine A S Langie (SAS)

VITO - Health, Mol, Belgium.
Theoretical Physics, Faculty of Sciences, Hasselt University, Hasselt, Belgium.
Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium.

Tom G Richardson (TG)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-7918-2040

Maria C Magnus (MC)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Ellen A Nohr (EA)

Research Unit for Gynaecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Zongli Xu (Z)

Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Liesbeth Duijts (L)

Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Department of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Shanshan Zhao (S)

Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, Durham, NC, USA.

Weiming Zhang (W)

Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Michelle Plusquin (M)

Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
MRC/PHE Centre for Environment and Health School of Public Health Imperial College London, St Mary's Campus, Norfolk Place, London, UK.

Dawn L DeMeo (DL)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Olivia Solomon (O)

School of Oral and Dental Sciences, University of Bristol, Bristol, UK.

Joosje H Heimovaara (JH)

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.

Dereje D Jima (DD)

Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.

Lu Gao (L)

Department of Preventive Medicine, University of Southern California, Los Angeles, CA, 90089, USA.

Mariona Bustamante (M)

ISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG), Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Patrice Perron (P)

Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada.

Robert O Wright (RO)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Irva Hertz-Picciotto (I)

Department of Public Health Sciences, School of Medicine, University of California Davis MIND Institute, Sacramento, CA, USA.

Hongmei Zhang (H)

Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.

Margaret R Karagas (MR)

Department of Epidemiology, Geisel School of Medicine at Dartmouth College, Hanover, NH, USA.
Children's Environmental Health & Disease Prevention Research Center at Dartmouth, Hanover, NH, USA.

Ulrike Gehring (U)

Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands.

Carmen J Marsit (CJ)

Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
ORCID: 0000-0003-4566-150X

Lawrence J Beilin (LJ)

Medical School, University of Western Australia, Perth, Australia.

Judith M Vonk (JM)

University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

Marjo-Riitta Jarvelin (MR)

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Biocenter Oulu, University of Oulu, Oulu, Finland.
Unit of Primary Care, Oulu University Hospital, Oulu, Finland.

Anna Bergström (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Center for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.

Anne K Örtqvist (AK)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Susan Ewart (S)

College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.

Pia M Villa (PM)

Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Sophie E Moore (SE)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
Department of Women and Children's Health, King's College London, London, UK.

Gonneke Willemsen (G)

Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Arnout R L Standaert (ARL)

VITO - Health, Mol, Belgium.

Siri E Håberg (SE)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Thorkild I A Sørensen (TIA)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-4821-430X

Jack A Taylor (JA)

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.

Katri Räikkönen (K)

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Ivana V Yang (IV)

Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Katerina Kechris (K)

Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Tim S Nawrot (TS)

Centre for Environmental Sciences, Hasselt University, Diepenbeek, Belgium.
Department of Public Health & Primary Care, Leuven University, Leuven, Belgium.

Matt J Silver (MJ)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.
ORCID: 0000-0002-3852-9677

Yun Yun Gong (YY)

School of Food Sciences and Nutrition, University of Leeds, Leeds, UK.

Lorenzo Richiardi (L)

Department of Medical Sciences, University of Turin, Turin, Italy.
AOU Citta della Salute e della Sceinza, CPO Piemonte, Turin, Italy.

Manolis Kogevinas (M)

ISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Augusto A Litonjua (AA)

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Brenda Eskenazi (B)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
Center for Environmental Research and Children's Health, School of Public Health, University of California, Berkeley, CA, USA.

Karen Huen (K)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Hamdi Mbarek (H)

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
ORCID: 0000-0002-1108-0371

Rachel L Maguire (RL)

Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
Department of Community and Family Medicine, Duke University Medical Center, Raleigh, NC, USA.

Terence Dwyer (T)

The George Institute for Global Health, Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.

Martine Vrijheid (M)

ISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Luigi Bouchard (L)

Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
ECOGENE-21 Biocluster, Chicoutimi Hospital, Saguenay, QC, Canada.

Andrea A Baccarelli (AA)

Laboratory of Precision Environmental Biosciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA.

Lisa A Croen (LA)

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
ORCID: 0000-0001-7849-9428

Wilfried Karmaus (W)

Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA.

Denise Anderson (D)

Telethon Kids Institute, University of Western Australia, Perth, Australia.
ORCID: 0000-0003-0643-4136

Maaike de Vries (M)

University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

Sylvain Sebert (S)

Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Biocenter Oulu, University of Oulu, Oulu, Finland.
Department for Genomics of Common Diseases, School of Public Health, Imperial College London, London, UK.

Juha Kere (J)

Folkhälsan Institute of Genetics, Helsinki, and Research Programs Unit, Molecular Neurology, University of Helsinki, Helsinki, Finland.
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
School of Basic and Medical Biosciences, King's College London, Guy's Hospital, London, UK.
ORCID: 0000-0003-1974-0271

Robert Karlsson (R)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-8949-2587

Syed Hasan Arshad (SH)

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
David Hide Asthma and Allergy Research Centre, Isle of Wight, UK.

Esa Hämäläinen (E)

HUSLAB and the Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland.

Michael N Routledge (MN)

LICAMM, School of Medicine, Univeristy of Leeds, Leeds, UK.

Dorret I Boomsma (DI)

Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Amsterdam Public Health Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Andrew P Feinberg (AP)

Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
ORCID: 0000-0002-8364-1991

Craig J Newschaffer (CJ)

AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.

Eva Govarts (E)

VITO - Health, Mol, Belgium.

Matthieu Moisse (M)

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), Leuven, Belgium.
VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium.
ORCID: 0000-0001-8880-9311

M Daniele Fallin (MD)

Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.

Erik Melén (E)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Sachs' Children's Hospital, Stockholm, Sweden.

Andrew M Prentice (AM)

Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, London, UK.

Eero Kajantie (E)

National Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.
Hospital for Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Catarina Almqvist (C)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Pediatric Allergy and Pulmonology Unit at Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden.

Emily Oken (E)

Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.

Dana Dabelea (D)

Department of Epidemiology, Colorado School of Public Health, and Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

H Marike Boezen (HM)

University of Groningen, University Medical Center Groningen, Department of Epidemiology and Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

Phillip E Melton (PE)

Centre for Genetic Origins of Health and Disease, School of Biomedical Sciences, University of Western Australia, Perth, Australia.
School of Pharmacy and Biomedical Sciences, Curtin University, Perth, Australia.
ORCID: 0000-0003-4026-2964

Rosalind J Wright (RJ)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Gerard H Koppelman (GH)

University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands.

Letizia Trevisi (L)

Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.

Marie-France Hivert (MF)

Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada.
Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.

Jordi Sunyer (J)

ISGlobal, Bacelona Institute for Global Health, Barcelona, Spain.
Universitat Pompeu Fabra (UPF), Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

Monica C Munthe-Kaas (MC)

Norwegian Institute of Public Health, Oslo, Norway.
Department of Pediatric Oncology and Hematology, Oslo University Hospital, Oslo, Norway.

Susan K Murphy (SK)

Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Eva Corpeleijn (E)

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands.

Joseph Wiemels (J)

Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

Nina Holland (N)

Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.

Zdenko Herceg (Z)

Epigenetics Group, International Agency for Research on Cancer, Lyon, France.

Elisabeth B Binder (EB)

Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Altanta, GA, USA.

George Davey Smith (G)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-1407-8314

Vincent W V Jaddoe (VWV)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
ORCID: 0000-0003-2939-0041

Rolv T Lie (RT)

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Wenche Nystad (W)

Department for Non-Communicable Diseases, Norwegian Institute for Public Health, Oslo, Norway.

Stephanie J London (SJ)

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Service, Research Triangle Park, Durham, NC, USA.
ORCID: 0000-0003-4911-5290

Debbie A Lawlor (DA)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. d.a.Lawlor@bristol.ac.uk.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. d.a.Lawlor@bristol.ac.uk.
ORCID: 0000-0002-6793-2262

Caroline L Relton (CL)

MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. caroline.relton@bristol.ac.uk.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. caroline.relton@bristol.ac.uk.

Harold Snieder (H)

University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands. h.snieder@umcg.nl.

Janine F Felix (JF)

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.
Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.
Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. j.felix@erasmusmc.nl.
ORCID: 0000-0002-9801-5774

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