Sex-Related Differences in Plasma Oxytocin Levels in Humans.
AVP receptors
Dymorphic changes
Humans
Oxytocin
Plasma levels
Social emotions
Journal
Clinical practice and epidemiology in mental health : CP & EMH
ISSN: 1745-0179
Titre abrégé: Clin Pract Epidemiol Ment Health
Pays: United Arab Emirates
ID NLM: 101245735
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
01
2019
revised:
19
02
2019
accepted:
22
02
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Increasing evidence supports a key role of Oxytocin (OT) as a modulator of social relationships in mammals. The aim of the present study was to investigate possible sex-related differences in plasma OT levels in human beings. Forty-five healthy men and 45 women (mean age: 34.9 ± 6.2 years), were included in the study. Plasma preparation, peptide extraction and OT radioimmunoassay were carried out according to standardized methods. The results showed that OT plasma levels (pg / ml, mean ± SD) were significantly higher in women than in men (4.53 ± 1.18 vs 1.53 ± 1.19, p ˂ 0.001). The present finding demonstrates sex-related differences in plasma OT levels in humans. It is tempting to hypothesize that such differences might be related to behaviours, attitudes, as well as susceptibility to stress response, resilience and social emotions specific of women and men.
Sections du résumé
BACKGROUND
BACKGROUND
Increasing evidence supports a key role of Oxytocin (OT) as a modulator of social relationships in mammals.
OBJECTIVE
OBJECTIVE
The aim of the present study was to investigate possible sex-related differences in plasma OT levels in human beings.
METHODS
METHODS
Forty-five healthy men and 45 women (mean age: 34.9 ± 6.2 years), were included in the study. Plasma preparation, peptide extraction and OT radioimmunoassay were carried out according to standardized methods.
RESULTS
RESULTS
The results showed that OT plasma levels (pg / ml, mean ± SD) were significantly higher in women than in men (4.53 ± 1.18 vs 1.53 ± 1.19, p ˂ 0.001).
CONCLUSIONS
CONCLUSIONS
The present finding demonstrates sex-related differences in plasma OT levels in humans. It is tempting to hypothesize that such differences might be related to behaviours, attitudes, as well as susceptibility to stress response, resilience and social emotions specific of women and men.
Identifiants
pubmed: 31015856
doi: 10.2174/1745017901915010058
pii: CPEMH-15-58
pmc: PMC6446474
doi:
Types de publication
Journal Article
Langues
eng
Pagination
58-63Références
Horm Behav. 2000 Feb;37(1):49-56
pubmed: 10712858
Exp Physiol. 2000 Mar;85 Spec No:111S-124S
pubmed: 10795913
Curr Opin Neurobiol. 2000 Dec;10(6):784-9
pubmed: 11240290
Prog Brain Res. 2002;139:43-55
pubmed: 12436925
Stress. 2002 Dec;5(4):269-76
pubmed: 12475731
Physiol Behav. 2003 Aug;79(3):383-97
pubmed: 12954433
Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5981-5
pubmed: 1321430
Biol Psychiatry. 2003 Dec 15;54(12):1389-98
pubmed: 14675803
Nat Neurosci. 2004 Aug;7(8):841-6
pubmed: 15273691
Nat Neurosci. 2004 Oct;7(10):1048-54
pubmed: 15452576
Z Psychosom Med Psychother. 2005;51(1):57-80
pubmed: 15834840
Nature. 2005 Jun 2;435(7042):673-6
pubmed: 15931222
Ann N Y Acad Sci. 1992 Jun 12;652:243-52
pubmed: 1626832
Neurosci Lett. 2006 Feb 13;394(2):146-51
pubmed: 16289323
Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17237-40
pubmed: 16303870
Neurosci Biobehav Rev. 1992 Summer;16(2):131-44
pubmed: 1630727
J Neurosci. 2005 Dec 7;25(49):11489-93
pubmed: 16339042
J Psychopharmacol. 2006 Sep;20(5):656-60
pubmed: 16401658
Biol Psychiatry. 2007 Feb 15;61(4):498-503
pubmed: 16904652
Behav Brain Res. 2007 Jan 10;176(1):170-86
pubmed: 17000015
Clin Pract Epidemiol Ment Health. 2006 Oct 11;2:28
pubmed: 17034623
Genes Brain Behav. 2008 Feb;7(1):70-7
pubmed: 17504245
Curr Med Chem. 2008;15(7):698-704
pubmed: 18336283
Neuron. 2008 May 22;58(4):639-50
pubmed: 18498743
J Neurosci. 2008 Jun 25;28(26):6607-15
pubmed: 18579733
CNS Neurosci Ther. 2008 Fall;14(3):165-70
pubmed: 18801109
Mol Psychiatry. 2009 Oct;14(10):954-8
pubmed: 18957940
Psychosom Med. 2008 Nov;70(9):967-75
pubmed: 19005082
Emotion. 2008 Dec;8(6):781-91
pubmed: 19102589
Biol Psychiatry. 2009 May 1;65(9):725-7
pubmed: 19348835
Psychoneuroendocrinology. 2010 Jan;35(1):83-93
pubmed: 19632787
Harv Rev Psychiatry. 2010 Jan-Feb;18(1):1-21
pubmed: 20047458
Psychol Sci. 2010 Jan;21(1):3-7
pubmed: 20424014
Psychiatry Res. 2010 Jul 30;178(2):359-62
pubmed: 20494448
Proc Biol Sci. 2011 Apr 22;278(1709):1189-94
pubmed: 20926437
Behav Neurosci. 2010 Oct;124(5):677-85
pubmed: 20939667
Eur Neuropsychopharmacol. 2012 Aug;22(8):578-83
pubmed: 22297159
Neuron. 2012 Feb 9;73(3):553-66
pubmed: 22325206
Soc Cogn Affect Neurosci. 2013 Mar;8(3):313-7
pubmed: 22446301
Trends Neurosci. 2012 Nov;35(11):649-59
pubmed: 22974560
Psychoneuroendocrinology. 2014 Jan;39:237-48
pubmed: 24157401
Brain Res. 2014 Sep 11;1580:124-32
pubmed: 24184577
Front Behav Neurosci. 2013 Dec 11;7:185
pubmed: 24376404
Int J Epidemiol. 2014 Apr;43(2):476-93
pubmed: 24648481
Acta Physiol (Oxf). 2014 Sep;212(1):97-105
pubmed: 24965868
Neurosci Biobehav Rev. 2014 Sep;45:305-22
pubmed: 25025656
Front Neuroendocrinol. 2016 Jan;40:1-23
pubmed: 25951955
Neuropsychobiology. 2015;72(2):74-80
pubmed: 26509891
Biol Psychiatry. 2016 Sep 1;80(5):406-14
pubmed: 26620251
Dialogues Clin Neurosci. 2015 Dec;17(4):463-76
pubmed: 26869847
Int J Geriatr Psychiatry. 2017 Jan;32(1):102-109
pubmed: 26898770
Psychoneuroendocrinology. 2016 Jul;69:50-9
pubmed: 27032063
Curr Opin Psychol. 2017 Feb;13:19-24
pubmed: 27135049
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7650-4
pubmed: 27325780
PLoS One. 2016 Jul 28;11(7):e0160059
pubmed: 27467763
Behav Pharmacol. 2016 Dec;27(8):659-671
pubmed: 27755016
J Neurosci Res. 2017 Jan 2;95(1-2):222-234
pubmed: 27870403
J Neurosci Res. 2017 Jan 2;95(1-2):719-730
pubmed: 27870443
Sci Rep. 2016 Dec 08;6:38662
pubmed: 27929138
Dialogues Clin Neurosci. 2017 Jun;19(2):193-201
pubmed: 28867943
Front Endocrinol (Lausanne). 2017 Dec 22;8:356
pubmed: 29312146
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6661-5
pubmed: 293752
Arch Gen Psychiatry. 1994 Oct;51(10):782-92
pubmed: 7524462
J Neurosci. 1995 Jul;15(7 Pt 1):5058-64
pubmed: 7623134
Neurosci Biobehav Rev. 1995 Summer;19(2):303-14
pubmed: 7630584
Adv Exp Med Biol. 1995;395:227-34
pubmed: 8713971
Acta Neurobiol Exp (Wars). 1996;56(3):779-85
pubmed: 8917906
Psychopharmacol Bull. 1997;33(2):185-92
pubmed: 9230630
Biol Psychiatry. 1998 Dec 15;44(12):1349-52
pubmed: 9861478
Psychoneuroendocrinology. 1998 Nov;23(8):945-62
pubmed: 9924746