Controlling nanoemulsion surface chemistry with poly(2-oxazoline) amphiphiles.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
14 Apr 2019
14 Apr 2019
Historique:
received:
21
12
2018
accepted:
26
02
2019
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Emulsions are dynamic materials that have been extensively employed within pharmaceutical, food and cosmetic industries. However, their use beyond conventional applications has been hindered by difficulties in surface functionalization, and an inability to selectively control physicochemical properties. Here, we employ custom poly(2-oxazoline) block copolymers to overcome these limitations. We demonstrate that poly(2-oxazoline) copolymers can effectively stabilize nanoscale droplets of hydrocarbon and perfluorocarbon in water. The controlled living polymerization of poly(2-oxazoline)s allows for the incorporation of chemical handles into the surfactants such that covalent modification of the emulsion surface can be performed. Through post-emulsion modification of these new surfactants, we are able to access nanoemulsions with modified surface chemistries, yet consistent sizes. By decoupling size and surface charge, we explore structure-activity relationships involving the cellular uptake of nanoemulsions in both macrophage and non-macrophage cell lines. We conclude that the cellular uptake and cytotoxicity of poly(2-oxazoline)-stabilized droplets can be systematically tuned
Identifiants
pubmed: 31015940
doi: 10.1039/c8sc05735d
pii: c8sc05735d
pmc: PMC6457192
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3994-4003Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM067555
Pays : United States
Références
Angew Chem Int Ed Engl. 2018 Dec 17;57(51):16742-16747
pubmed: 30375721
Expert Opin Drug Deliv. 2016 Sep;13(9):1327-36
pubmed: 26984045
Allergy Asthma Immunol Res. 2012 Jan;4(1):46-8
pubmed: 22211170
Biomaterials. 2010 Apr;31(11):3079-86
pubmed: 20092889
Nat Nanotechnol. 2010 Jan;5(1):15-25
pubmed: 20032986
Biochemistry. 1998 Sep 15;37(37):12875-83
pubmed: 9737866
Annu Rev Chem Biomol Eng. 2010;1:149-73
pubmed: 22432577
J Am Chem Soc. 2013 May 1;135(17):6392-5
pubmed: 23527630
Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1540-73
pubmed: 20166107
Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2004-2021
pubmed: 11433435
Soft Matter. 2016 Mar 21;12(11):2826-41
pubmed: 26924445
J Agric Food Chem. 2009 Oct 14;57(19):9181-9
pubmed: 19807163
Nat Nanotechnol. 2007 Dec;2(12):751-60
pubmed: 18654426
Ann Surg. 1982 Jan;195(1):60-9
pubmed: 7034658
Adv Colloid Interface Sci. 2004 May 20;108-109:145-9
pubmed: 15072937
Biomaterials. 2011 May;32(13):3435-46
pubmed: 21295849
Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11404-11408
pubmed: 28816007
Int J Nanomedicine. 2012;7:5577-91
pubmed: 23144561
J Control Release. 2011 Aug 10;153(3):198-205
pubmed: 21663778
ACS Nano. 2017 Jun 27;11(6):6085-6101
pubmed: 28562003
Pediatrics. 2011 Oct;128(4):e1025-8
pubmed: 21911353
Mol Pharm. 2008 Jul-Aug;5(4):505-15
pubmed: 18672949
Nat Biotechnol. 2015 Sep;33(9):941-51
pubmed: 26348965
Bioconjug Chem. 2011 May 18;22(5):976-86
pubmed: 21452890
ACS Nano. 2015 Oct 27;9(10):9986-93
pubmed: 26435075
Small. 2010 Jan;6(1):12-21
pubmed: 19844908
ACS Nano. 2015 Oct 27;9(10):10227-36
pubmed: 26327513
J Am Chem Soc. 2013 Dec 11;135(49):18445-57
pubmed: 24266634
Science. 2004 Jan 16;303(5656):348-51
pubmed: 14726585
J Am Chem Soc. 2015 Jan 28;137(3):1362-71
pubmed: 25603470
Adv Colloid Interface Sci. 2006 Dec 21;128-130:47-64
pubmed: 17229398
Expert Opin Drug Deliv. 2007 Jul;4(4):403-16
pubmed: 17683253
Nature. 2008 Sep 4;455(7209):85-8
pubmed: 18769436
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15344-9
pubmed: 25316794
Science. 2010 Jul 9;329(5988):197-200
pubmed: 20616274
ACS Macro Lett. 2018 Jan 16;7(1):7-10
pubmed: 35610932
Small. 2013 Nov 25;9(22):3736-42
pubmed: 23606503
Chem Soc Rev. 2012 Apr 7;41(7):2537-8
pubmed: 22388450
Angew Chem Int Ed Engl. 2018 Nov 19;57(47):15400-15404
pubmed: 30303605
J Am Chem Soc. 2001 Oct 17;123(41):10101-2
pubmed: 11592891
Nature. 2015 Aug 27;524(7566):450-3
pubmed: 26310766
Ann Biomed Eng. 2009 Oct;37(10):1922-33
pubmed: 19184435
Biointerphases. 2012 Dec;7(1-4):1
pubmed: 22589044
Chem Sci. 2016 Aug 1;7(8):5091-5097
pubmed: 30155158
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(2):215-34
pubmed: 8087244
Nano Today. 2015 Aug;10(4):487-510
pubmed: 26640510
Int J Nanomedicine. 2006;1(3):297-315
pubmed: 17717971
Nanomedicine (Lond). 2014 Feb;9(2):313-30
pubmed: 24552563
ACS Nano. 2015 Jul 28;9(7):6996-7008
pubmed: 26079146
Expert Opin Drug Deliv. 2012 Nov;9(11):1319-23
pubmed: 22931049
J Control Release. 2008 Jun 24;128(3):185-99
pubmed: 18374443
J Cosmet Sci. 2006 Mar-Apr;57(2):153-69
pubmed: 16688378
Int J Cancer. 2003 Jul 1;105(4):561-7
pubmed: 12712451
J Am Chem Soc. 2006 Aug 16;128(32):10521-6
pubmed: 16895419
Pharm Res. 2010 Jan;27(1):1-16
pubmed: 19902338
Soft Matter. 2017 Nov 8;13(43):7953-7961
pubmed: 29038804
Nat Commun. 2015 Nov 03;6:8785
pubmed: 26525216
Adv Drug Deliv Rev. 2000 Dec 6;45(1):89-121
pubmed: 11104900
J Colloid Interface Sci. 2015 Oct 1;455:172-8
pubmed: 26070187
J Am Chem Soc. 2012 Feb 1;134(4):2139-47
pubmed: 22191645
J Am Chem Soc. 2018 Apr 4;140(13):4469-4472
pubmed: 29562135
Macromol Biosci. 2016 Sep;16(9):1287-300
pubmed: 27281039
Nature. 2018 Jan 18;553(7688):313-318
pubmed: 29320473
Annu Rev Phys Chem. 2012;63:493-518
pubmed: 22475339
Nat Mater. 2006 Jun;5(6):502-6
pubmed: 16715085
ACS Nano. 2015 Jul 28;9(7):7195-206
pubmed: 26149286
Small. 2011 May 23;7(10):1322-37
pubmed: 21520409
Int J Radiat Oncol Biol Phys. 1984 Aug;10(8):1421-4
pubmed: 6547941
Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13351-13356
pubmed: 28760977
Artif Cells Blood Substit Immobil Biotechnol. 2001 Nov;29(6):483-92
pubmed: 11795633
Biomacromolecules. 2005 Jul-Aug;6(4):1824-8
pubmed: 16004414
ACS Nano. 2016 May 24;10(5):5536-42
pubmed: 27164169
J Am Chem Soc. 2008 Mar 5;130(9):2832-41
pubmed: 18266363
Lab Chip. 2017 Feb 14;17(4):635-639
pubmed: 28154857
ACS Nano. 2017 Oct 24;11(10):9877-9888
pubmed: 28972735
Int J Nanomedicine. 2012;7:799-813
pubmed: 22359457
J Am Chem Soc. 2016 Sep 7;138(35):11306-11
pubmed: 27517465
J Agric Food Chem. 2011 Jun 8;59(11):6247-55
pubmed: 21520914
Org Lett. 2018 Nov 2;20(21):6850-6854
pubmed: 30354161
Chem Commun (Camb). 2013 Oct 21;49(82):9392-4
pubmed: 23877789
J Am Chem Soc. 2014 Oct 1;136(39):13574-7
pubmed: 25229987
Artif Cells Blood Substit Immobil Biotechnol. 1994;22(4):955-63
pubmed: 7849967
Adv Colloid Interface Sci. 2006 Dec 21;128-130:227-48
pubmed: 17223060
Adv Colloid Interface Sci. 2018 Jan;251:55-79
pubmed: 29248154
J Drug Deliv. 2011;2011:727241
pubmed: 21512579
Angew Chem Int Ed Engl. 2010 Aug 23;49(36):6288-308
pubmed: 20648499
J Am Chem Soc. 2017 Jan 11;139(1):15-18
pubmed: 28032757
Langmuir. 2017 Aug 15;33(32):7957-7967
pubmed: 28732169
J Agric Food Chem. 2010 Sep 8;58(17):9825-32
pubmed: 20707308
Chem Soc Rev. 2005 Mar;34(3):276-85
pubmed: 15726163
Chem Commun (Camb). 2017 Dec 5;53(97):13043-13046
pubmed: 29164187
Nature. 2015 Feb 26;518(7540):520-4
pubmed: 25719669