Effect of Vitamin D Supplementation on Bone Turnover Markers in Children and Adolescents from North India.
bone markers
parathormone
procollagen type-1 amino-terminal propeptide
serum 25OHD
vitamin D deficiency
β-Cross laps
Journal
Indian journal of endocrinology and metabolism
ISSN: 2230-8210
Titre abrégé: Indian J Endocrinol Metab
Pays: India
ID NLM: 101555690
Informations de publication
Date de publication:
Historique:
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
ppublish
Résumé
Vitamin D is known to play an important role in bone mineral metabolism. Its deficiency may affect growth and status of bone markers in children. Hence, we undertook to study the status of bone markers in children with vitamin D deficiency (VDD) and impact of vitamin D3 supplementation on them. Total 468 out of 615 children and adolescents with VDD, who were given either of the three doses (600, 1000, and 2000) of vitamin D supplementation, were included in the study. These 468 children with pre- and postsupplementation preserved samples with available anthropometry, serum biochemistry, 25-hydroxy-vitamin D, and parathormone were evaluated for bone formation (procollagen type 1 amino-terminal propeptide [P1NP]) and resorption (β-cross laps [CTx]) markers. The mean age and body mass index of these children were 11.3 ± 2.3 years (boys: 11.5 ± 2.4; girls: 12.2 ± 1.2 years; Vitamin D supplementation in VDD children resulted in decrease in both bone formation (P1NP) and resorption (CTx). The impact, however, was more marked on bone resorption than bone formation.
Identifiants
pubmed: 31016149
doi: 10.4103/ijem.IJEM_149_18
pii: IJEM-23-27
pmc: PMC6446672
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27-34Déclaration de conflit d'intérêts
There are no conflicts of interest.
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