A Comparison between Silent and Symptomatic Renal Stones in Primary Hyperparathyroidism.
Microlithiais
nephrolithiasis
primary hyperparathyroidism
silent renal stones
Journal
Indian journal of endocrinology and metabolism
ISSN: 2230-8210
Titre abrégé: Indian J Endocrinol Metab
Pays: India
ID NLM: 101555690
Informations de publication
Date de publication:
Historique:
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
ppublish
Résumé
Nephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and in a subgroup of patients stones are clinically silent. Patients with silent and symptomatic stones may differ biochemically. There is a scarcity of data available comparing patients with silent and symptomatic renal stones in PHPT. To characterize patients with PHPT with nephrolithiais and to compare patients with silent and symptomatic stones. We reviewed clinical data of 186 patients with PHPT managed at our center from January 1996 to December 2017. Silent renal stones were defined as ultrasonography finding of renal stones without symptoms. Symptomatic renal stones were defined as those with symptoms or a history of graveluria or any procedure for nephrolithiasis. A 5-mm diameter was set as the cut-off between micro- and macrolithiasis. We compared those with ( There was no significant difference between stone formers and nonstone formers with respect to biochemical parameters. Patients with silent renal stones had significantly lower serum calcium and higher phosphate, than those with symptomatic stones. Most (75%) patients with silent renal stones had microlithiais, while only a fifth (22%) with symptomatic renal stones had microlithiasis. Nephrolithiasis is a common complication of PHPT. Most patients with silent renal stones had microlithiasis and biochemical features of less severe disease. Patients with silent renal stones may represent early mild stage of PHPT.
Sections du résumé
BACKGROUND
BACKGROUND
Nephrolithiasis is a common complication of primary hyperparathyroidism (PHPT), and in a subgroup of patients stones are clinically silent. Patients with silent and symptomatic stones may differ biochemically. There is a scarcity of data available comparing patients with silent and symptomatic renal stones in PHPT.
AIMS
OBJECTIVE
To characterize patients with PHPT with nephrolithiais and to compare patients with silent and symptomatic stones.
MATERIALS AND METHODS
METHODS
We reviewed clinical data of 186 patients with PHPT managed at our center from January 1996 to December 2017. Silent renal stones were defined as ultrasonography finding of renal stones without symptoms. Symptomatic renal stones were defined as those with symptoms or a history of graveluria or any procedure for nephrolithiasis. A 5-mm diameter was set as the cut-off between micro- and macrolithiasis. We compared those with (
RESULTS
RESULTS
There was no significant difference between stone formers and nonstone formers with respect to biochemical parameters. Patients with silent renal stones had significantly lower serum calcium and higher phosphate, than those with symptomatic stones. Most (75%) patients with silent renal stones had microlithiais, while only a fifth (22%) with symptomatic renal stones had microlithiasis.
CONCLUSION
CONCLUSIONS
Nephrolithiasis is a common complication of PHPT. Most patients with silent renal stones had microlithiasis and biochemical features of less severe disease. Patients with silent renal stones may represent early mild stage of PHPT.
Identifiants
pubmed: 31016152
doi: 10.4103/ijem.IJEM_558_18
pii: IJEM-23-46
pmc: PMC6446667
doi:
Types de publication
Journal Article
Langues
eng
Pagination
46-49Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Endocr Pract. 2002 Jul-Aug;8(4):266-70
pubmed: 12173912
J Am Soc Nephrol. 2002 Oct;13(10):2517-23
pubmed: 12239240
Kidney Int. 2003 May;63(5):1817-23
pubmed: 12675858
Otolaryngol Head Neck Surg. 2005 Mar;132(3):359-72
pubmed: 15746845
J Clin Endocrinol Metab. 2007 Jan;92(1):277-83
pubmed: 17018660
Urol Res. 2007 Jun;35(3):123-8
pubmed: 17476495
Urol Clin North Am. 2007 Aug;34(3):323-34
pubmed: 17678983
AJR Am J Roentgenol. 2008 Sep;191(3):908-11
pubmed: 18716127
J Urol. 2009 May;181(5):2141-5
pubmed: 19296981
J Clin Endocrinol Metab. 2011 Aug;96(8):2377-85
pubmed: 21646371
Eur J Endocrinol. 2012 Jun;166(6):1093-100
pubmed: 22474170
Endocr Pract. 2014 Nov;20(11):1137-42
pubmed: 24936557
J Clin Endocrinol Metab. 2014 Oct;99(10):3561-9
pubmed: 25162665
J Clin Endocrinol Metab. 2015 Apr;100(4):1309-15
pubmed: 25646791
Endocrine. 2017 Jan;55(1):256-265
pubmed: 27033542
Indian J Endocrinol Metab. 2016 Sep-Oct;20(5):696-701
pubmed: 27730083
Endocr Pract. 2017 Feb;23(2):157-162
pubmed: 27819765
Surgery. 1996 Dec;120(6):1033-7; discussion 1037-8
pubmed: 8957491