Polymorphic Analysis of Leptin Promoter in Obese/diabetic Subjects in Kashmiri Population.
Diabetes
leptin
leptin receptor
obesity
single-nucleotide polymorphisms
Journal
Indian journal of endocrinology and metabolism
ISSN: 2230-8210
Titre abrégé: Indian J Endocrinol Metab
Pays: India
ID NLM: 101555690
Informations de publication
Date de publication:
Historique:
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
ppublish
Résumé
The role of common variants in leptin promoter has already been established to play a major role in obesity and diabetes in humans. The study was accordingly focused on leptin promoter variants and their potential association with diabetes and obesity in ethnic population from Kashmir, India. Allele frequencies of 620 Kashmiri subjects with diabetes (200), obese subjects (200), and ethnically matched healthy controls (200) were tested for the Hardy-Weinberg disequilibrium. Among 200 obese subjects, a total of 50 persons were with diabetes. The genotype and allele frequencies were evaluated using the Chi-square or Fisher's exact tests. Sequence analysis revealed two reported variations i.e., rs72563764C>T and rs7799039G>A in promoter region. Both variants show homozygous as well as heterozygous genotypes. These variations indicated significant difference with respect to allelic and genotypic frequencies in all groups i.e., persons with diabetes, obese, and obese persons with diabetes ( Our results are suggestive of the association of leptin promoter gene variations i.e., rs72563764C>T and rs7799039G>A with both diabetes and obesity.
Sections du résumé
BACKGROUND
BACKGROUND
The role of common variants in leptin promoter has already been established to play a major role in obesity and diabetes in humans. The study was accordingly focused on leptin promoter variants and their potential association with diabetes and obesity in ethnic population from Kashmir, India.
METHODS
METHODS
Allele frequencies of 620 Kashmiri subjects with diabetes (200), obese subjects (200), and ethnically matched healthy controls (200) were tested for the Hardy-Weinberg disequilibrium. Among 200 obese subjects, a total of 50 persons were with diabetes. The genotype and allele frequencies were evaluated using the Chi-square or Fisher's exact tests.
RESULTS
RESULTS
Sequence analysis revealed two reported variations i.e., rs72563764C>T and rs7799039G>A in promoter region. Both variants show homozygous as well as heterozygous genotypes. These variations indicated significant difference with respect to allelic and genotypic frequencies in all groups i.e., persons with diabetes, obese, and obese persons with diabetes (
CONCLUSIONS
CONCLUSIONS
Our results are suggestive of the association of leptin promoter gene variations i.e., rs72563764C>T and rs7799039G>A with both diabetes and obesity.
Identifiants
pubmed: 31016164
doi: 10.4103/ijem.IJEM_164_18
pii: IJEM-23-111
pmc: PMC6446689
doi:
Types de publication
Journal Article
Langues
eng
Pagination
111-116Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
J Clin Endocrinol Metab. 2000 Jan;85(1):29-34
pubmed: 10634359
Ann Hum Genet. 1999 May;63(Pt 3):227-34
pubmed: 10738535
Ann Hum Genet. 2000 Sep;64(Pt 5):391-4
pubmed: 11281277
J Clin Endocrinol Metab. 2001 Sep;86(9):4434-9
pubmed: 11549688
Horm Metab Res. 2002 Jul;34(7):355-9
pubmed: 12189581
Zhonghua Yi Xue Za Zhi. 2003 Dec 25;83(24):2119-23
pubmed: 14720418
Am J Hum Genet. 2004 Aug;75(2):220-30
pubmed: 15197684
Am J Epidemiol. 2005 Jul 15;162(2):101-14
pubmed: 15972940
Hormones (Athens). 2003 Oct-Dec;2(4):229-36
pubmed: 17003027
Eur J Epidemiol. 2006;21(8):605-12
pubmed: 17031518
Genet Mol Res. 2007 Oct 05;6(4):1035-43
pubmed: 18273796
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Apr;33(4):316-20
pubmed: 18460775
Nutr Neurosci. 2008 Feb;11(1):2-8
pubmed: 18510797
Blood Press. 2008;17(5-6):278-83
pubmed: 18923972
Clin Biochem. 2009 May;42(7-8):584-8
pubmed: 19041299
J Clin Psychopharmacol. 2009 Feb;29(1):21-5
pubmed: 19142102
Psychiatr Genet. 2009 Dec;19(6):320-7
pubmed: 19873684
Biochem Biophys Res Commun. 2010 Jan 1;391(1):282-6
pubmed: 19913498
Arq Bras Endocrinol Metabol. 2010 Mar;54(3):282-8
pubmed: 20520958
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Jul;13(7):539-42
pubmed: 21752317
Genet Test Mol Biomarkers. 2012 Jul;16(7):726-33
pubmed: 22734460
Cell Biochem Biophys. 2013 Mar;65(2):243-7
pubmed: 23054910
Front Med. 2013 Jun;7(2):207-22
pubmed: 23580174
Asian Pac J Trop Med. 2017 Oct;10(10):940-944
pubmed: 29111188
J Biol Chem. 1996 Feb 23;271(8):3971-4
pubmed: 8626726
Nature. 1996 Feb 15;379(6566):632-5
pubmed: 8628397
Diabetes. 1998 Mar;47(3):487-9
pubmed: 9519759
Nature. 1998 Mar 26;392(6674):398-401
pubmed: 9537324
Nature. 1998 Oct 22;395(6704):763-70
pubmed: 9796811