Local transgene expression and whole-body transgenesis to model brain diseases in nonhuman primate.
animal models
neuroscience
nonhuman primates
Journal
Animal models and experimental medicine
ISSN: 2576-2095
Titre abrégé: Animal Model Exp Med
Pays: United States
ID NLM: 101726292
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
18
09
2018
accepted:
10
12
2018
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
25
4
2019
Statut:
epublish
Résumé
Animal model is an essential tool in the life sciences research, notably in understanding the pathogenesis of the diseases and for further therapeutic intervention success. Rodents have been the most frequently used animals to model human disease since the establishment of gene manipulation technique. However, they remain inadequate to fully mimic the pathophysiology of human brain disease, partially due to huge differences between rodents and humans in terms of anatomy, brain function, and social behaviors. Nonhuman primates are more suitable in translational perspective. Thus, genetically modified animals have been generated to investigate neurologic and psychiatric disorders. The classical transgenesis technique is not efficient in that model; so, viral vector-mediated transgene delivery and the new genome-editing technologies have been promoted. In this review, we summarize some of the technical progress in the generation of an ad hoc animal model of brain diseases by gene delivery and real transgenic nonhuman primate.
Identifiants
pubmed: 31016282
doi: 10.1002/ame2.12055
pii: AME212055
pmc: PMC6431118
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
9-17Déclaration de conflit d'intérêts
None.
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