Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in

Benzhydryl Compounds / chemistry Drug Resistance, Bacterial / drug effects Drug Stability Homeostasis / drug effects Humans Hydrogen-Ion Concentration / drug effects Microsomes, Liver / chemistry Molecular Structure Mycobacterium tuberculosis / drug effects Phenols / chemical synthesis Structure-Activity Relationship
None agrimophol coumarin diphenylmethane scaffold intrabacterial pH homeostasis pharmacophores

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
12 07 2019
Historique:
pubmed: 25 4 2019
medline: 27 6 2020
entrez: 25 4 2019
Statut: ppublish

Résumé

This article reports the rational medicinal chemistry of a natural product, agrimophol (

Identifiants

DOI: 10.1021/acsinfecdis.8b00325 PMID: 31016962
pubmed: 31016962
doi: 10.1021/acsinfecdis.8b00325
doi:

Substances chimiques

Benzhydryl Compounds 0
Phenols 0
agrimophol 65792-05-4
diphenylmethane K3E387I0BC

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1087-1104

Auteurs

Jie Wu (J)

Tsinghua-Peking Center for Life Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

Ran Mu (R)

School of Pharmaceutical Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

Mingna Sun (M)

School of Pharmaceutical Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

Nan Zhao (N)

Department of Microbiology and Immunology , Weill Cornell Medical College , New York , New York 10065 , United States.

Miaomiao Pan (M)

Centre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases , Tsinghua University School of Medicine , Beijing 100084 , China.

Hongshuang Li (H)

School of Pharmaceutical Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

Yi Dong (Y)

School of Pharmaceutical Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.

Zhaogang Sun (Z)

National Tuberculosis Clinical Laboratory, Beijing Chest Hospital, Capital Medical University and Beijing Key Laboratory in Drug Resistant Tuberculosis Research , Beijing Tuberculosis & Thoracic Tumor Research Institute , 9 Beiguan Street , Tongzhou District, Beijing 101149 , China.

Jie Bai (J)

Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street , Beijing 100050 , China.

Minwan Hu (M)

Institute of Materia Medica , Chinese Academy of Medical Sciences & Peking Union Medical College , 1 Xian Nong Tan Street , Beijing 100050 , China.

Carl F Nathan (CF)

Department of Microbiology and Immunology , Weill Cornell Medical College , New York , New York 10065 , United States.

Babak Javid (B)

Centre for Global Health and Infectious Diseases, Collaborative Innovation Centre for the Diagnosis and Treatment of Infectious Diseases , Tsinghua University School of Medicine , Beijing 100084 , China.
ORCID: 0000-0002-6354-6305

Gang Liu (G)

Tsinghua-Peking Center for Life Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.
School of Pharmaceutical Sciences , Tsinghua University , Renhuan Building, Rm 311 , Haidian District, Beijing 100084 , P. R. China.
ORCID: 0000-0001-5549-5686

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance bactérienne aux médicaments › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Techniques d'investigation › Stabilité de médicament › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Derivatives of Natural Product Agrimophol as...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Derivatives of Natural Product Agrimophol as...