Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.
Anti-Citrullinated Protein Antibodies
/ metabolism
Antigens, CD1
/ metabolism
Arthritis, Rheumatoid
/ immunology
Cell Differentiation
Cell Lineage
Cell Plasticity
Cell Transdifferentiation
Cells, Cultured
Citrullination
Dendritic Cells
/ physiology
Humans
Interleukin-8
/ metabolism
Monocytes
/ cytology
Osteoclasts
/ physiology
Protein-Arginine Deiminases
/ metabolism
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 06 2019
01 06 2019
Historique:
received:
16
04
2018
accepted:
21
03
2019
pubmed:
26
4
2019
medline:
27
2
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
An increased repertoire of potential osteoclast (OC) precursors could accelerate the development of bone-erosive OCs and the consequent bone damage in rheumatoid arthritis (RA). Immature dendritic cells (DCs) can develop into OCs, however, the mechanisms underlying this differentiation switch are poorly understood. We investigated whether protein citrullination and RA-specific anti-citrullinated protein Abs (ACPAs) could regulate human blood-derived DC-OC transdifferentiation. We show that plasticity toward the OC lineage correlated with peptidyl arginine deiminase (PAD) activity and protein citrullination in DCs. Citrullinated actin and vimentin were present in DCs and DC-derived OCs, and both proteins were deposited on the cell surface, colocalizing with ACPAs binding to the cells. ACPAs enhanced OC differentiation from monocyte-derived or circulating CD1c
Identifiants
pubmed: 31019059
pii: jimmunol.1800534
doi: 10.4049/jimmunol.1800534
pmc: PMC6526390
doi:
Substances chimiques
Anti-Citrullinated Protein Antibodies
0
Antigens, CD1
0
Interleukin-8
0
Protein-Arginine Deiminases
EC 3.5.3.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3143-3150Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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