Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis.
PP2A
centromere pairing
meiosis
nonexchange chromosome
shugoshin
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
07 05 2019
07 05 2019
Historique:
pubmed:
26
4
2019
medline:
17
3
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
Faithful chromosome segregation during meiosis I depends upon the formation of connections between homologous chromosomes. Crossovers between homologs connect the partners, allowing them to attach to the meiotic spindle as a unit, such that they migrate away from one another at anaphase I. Homologous partners also become connected by pairing of their centromeres in meiotic prophase. This centromere pairing can promote proper segregation at anaphase I of partners that have failed to become joined by a crossover. Centromere pairing is mediated by synaptonemal complex (SC) proteins that persist at the centromere when the SC disassembles. Here, using mouse spermatocyte and yeast model systems, we tested the role of shugoshin in promoting meiotic centromere pairing by protecting centromeric synaptonemal components from disassembly. The results show that shugoshin protects the centromeric SC in meiotic prophase and, in anaphase, promotes the proper segregation of partner chromosomes that are not linked by a crossover.
Identifiants
pubmed: 31019073
pii: 1902526116
doi: 10.1073/pnas.1902526116
pmc: PMC6511000
doi:
Substances chimiques
Cell Cycle Proteins
0
shugoshin protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9417-9422Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103636
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM087377
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125803
Pays : United States
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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