Metabolomic profiling to identify effects of dietary calcium reveal the influence of the individual and postprandial dynamics on the canine plasma metabolome.
BW, body weight
Canine nutrition
Individual metabolomes
Nutritional metabolomics
Postprandial metabolomes
Journal
Journal of nutritional science
ISSN: 2048-6790
Titre abrégé: J Nutr Sci
Pays: England
ID NLM: 101590587
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
11
2018
revised:
28
02
2019
accepted:
12
03
2019
entrez:
26
4
2019
pubmed:
26
4
2019
medline:
26
4
2019
Statut:
epublish
Résumé
Short-term feeding studies have highlighted a phenomenon in Ca regulation that raises concerns around Ca absorption in dogs that may make an impact on commercial diets near to the maximum recommended level. A recent study to determine responses in dogs fed one of two diets differing in dietary Ca over 40 weeks found no evidence to suggest a concern across a range of biological parameters hypothesised to be affected by Ca. Unforeseen consequences of dietary Ca could have occurred and metabolic profiling was deemed a suitable data-driven approach to identify effects of dietary Ca. The objectives were to compare the fasted plasma metabolome (sampled at 8-week intervals over 40 weeks) of dogs fed one of two diets, near to the minimum and maximum recommended levels of dietary Ca. Comparisons with the control diet were also investigated across the postprandial time course (1-4 h) following acute (1 d) and long-term (24 weeks) feeding of the test diet. Comparing fasted plasma samples at each time point, no significant effect (adjusted
Identifiants
pubmed: 31019684
doi: 10.1017/jns.2019.12
pii: 00012
pmc: PMC6465680
doi:
Substances chimiques
Calcium, Dietary
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13Références
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