Epigenetic Factors in Schizophrenia: Mechanisms and Experimental Approaches.
Epigenetics
Omics
Schizophrenia
Journal
Molecular neuropsychiatry
ISSN: 2296-9209
Titre abrégé: Mol Neuropsychiatry
Pays: Switzerland
ID NLM: 101649121
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
02
08
2018
accepted:
30
10
2018
entrez:
26
4
2019
pubmed:
26
4
2019
medline:
26
4
2019
Statut:
ppublish
Résumé
Schizophrenia is a chronic mental disorder that is still poorly understood despite decades of study. Many factors have been found to contribute to the pathogenesis, including neurodevelopmental disturbance, genetic risk, and environmental insult, but no single root cause has emerged. While evidence from twin studies suggests a strong heritable component, few individual loci have been identified in genomewide screens, suggesting a role for epigenetic effects. Rather, large numbers of weakly acting loci may cumulatively increase disease risk, including several mapping to epigenetic pathways. In this review, we discuss mechanisms of epigenetic regulation and evidence for an epigenetic contribution to disease phenotype. We further describe the range of experimental tools currently available to study epigenetic effects associated with the disease.
Identifiants
pubmed: 31019914
doi: 10.1159/000495063
pii: mnp-0005-0006
pmc: PMC6465752
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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