B Cell-Activating Factor Is Associated with Testosterone and Smoking Status in Non-Ambulatory Men with Chronic Spinal Cord Injury.
B cell–activating factor (BAFF)
biomarker
rehabilitation medicine
spinal cord injury
testosterone
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
15 12 2019
15 12 2019
Historique:
pubmed:
26
4
2019
medline:
11
11
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
B cell-mediated autoimmunity may contribute to poor neurological outcomes after spinal cord injury (SCI). B cell-activating factor (BAFF) is a key cytokine involved in B cell development, proliferation, activation, and survival whose expression is elevated in men with chronic SCI. The aim of this study was to assess factors associated with circulating BAFF in non-ambulatory males with chronic SCI. We assessed the association between clinical and demographic factors, health habits, and circulating BAFF levels in a convenience sample of 43 non-ambulatory men with chronic spinal cord injury (≥ 1 year post-injury). Serum BAFF and total testosterone levels were quantified by enzyme-linked immunosorbent assay. Body composition was determined by whole body dual-energy X-ray absorptiometry. In multivariable models, active smokers had significantly greater BAFF levels than former/nonsmokers (871 pg/mL vs. 665 pg/ml,
Identifiants
pubmed: 31020912
doi: 10.1089/neu.2018.6221
pmc: PMC6892431
doi:
Substances chimiques
B-Cell Activating Factor
0
B-Cell Activation Factor Receptor
0
Biomarkers
0
TNFSF13B protein, human
0
Testosterone
3XMK78S47O
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3332-3337Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR064793
Pays : United States
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