Diagnostic and Therapeutic Uptake of Intrathyroid Metastasis of Midgut Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT and 177Lu-DOTATATE Imaging.
Journal
Clinical nuclear medicine
ISSN: 1536-0229
Titre abrégé: Clin Nucl Med
Pays: United States
ID NLM: 7611109
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
pubmed:
26
4
2019
medline:
16
8
2019
entrez:
26
4
2019
Statut:
ppublish
Résumé
A 58-year-old woman with 5-year history of grade 1 progressive metastatic intestinal neuroendocrine tumor with metachronous liver metastases initially treated by surgery and liver embolization underwent Ga-DOTANOC PET/CT before Lu-DOTATATE therapy. Ga-DOTANOC PET/CT revealed increased uptake in several liver metastases and right iliac lymph nodes, consistent with radiopeptide therapy, including a hypodense isthmic thyroid nodule. Fine needle ultrasound-guided biopsy of the thyroid nodule was realized. Immunohistochemistry was positive for CD56, chromogranin, and synaptophysin and negative for calcitonin, confirming neuroendocrine tumor intrathyroid metastasis. Lu-DOTATATE SPECT/CT showed therapeutic uptake on the thyroid metastasis.
Identifiants
pubmed: 31021912
doi: 10.1097/RLU.0000000000002586
doi:
Substances chimiques
68Ga-DOTANOC
0
Organometallic Compounds
0
Radiopharmaceuticals
0
lutetium Lu 177 dotatate
AE221IM3BB
Octreotide
RWM8CCW8GP
Types de publication
Case Reports
Journal Article
Langues
eng