Antidepressive effects of a chemically characterized maqui berry extract (Aristotelia chilensis (molina) stuntz) in a mouse model of Post-stroke depression.

Animals Antidepressive Agents / pharmacology Depression / drug therapy Disease Models, Animal Elaeocarpaceae / chemistry Mice Plant Extracts / pharmacology Stroke / complications
Chemical characterization In vivo antioxidant activity Maqui berry extract Murine model system Post-stroke depression

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
Jul 2019
Historique:
received: 14 01 2019
revised: 10 04 2019
accepted: 15 04 2019
pubmed: 26 4 2019
medline: 30 7 2019
entrez: 26 4 2019
Statut: ppublish

Résumé

Mood disorders occur in 30% of stroke patients, and of these post-stroke depression (PSD) is the most significant. This study aimed to evaluate the antidepressive-like effects and in vivo antioxidant activity of a chemically characterized maqui berry (Aristotelia chilensis (Molina) Stuntz) extract obtained from an optimized extraction method, on a murine PSD model. The extraction process was optimized to maximize anthocyanin content, and the phytochemical profile of the extract was evaluated using a multi-methodological approach including a liquid chromatographic method coupled with mass spectrometry and nuclear magnetic resonance spectroscopy. The antidepressive-like activity was investigated through despair swimming and tail suspension tests. The in vivo antioxidant activity was evaluated in mouse brain tissue by measuring the activity of antioxidant enzymes and lipid peroxidation products. A number of compounds have been first identified in maqui berry here, including malvidin-glucoside, GABA, choline and trigonelline. Moreover, the results showed that the antidepressive-like activity exerted by the extract, which was found to restore normal mouse behavior in both despair swimming and tail suspension tests, could be linked to its antioxidant activity, leading to the conclusion that maqui berries might be useful for supporting pharmacological therapy of PSD by modulating oxidative stress.

Identifiants

DOI: 10.1016/j.fct.2019.04.023 PMID: 31022478
pubmed: 31022478
pii: S0278-6915(19)30222-4
doi: 10.1016/j.fct.2019.04.023
pii:
doi:

Substances chimiques

Antidepressive Agents 0
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Pagination

434-443

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Arianna Di Lorenzo (A)

Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: arianna.dilorenzo1@gmail.com.

Anatoly P Sobolev (AP)

Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, 00015, Monterotondo (Rome), Italy. Electronic address: anatoly.sobolev@cnr.it.

Seyed Fazel Nabavi (SF)

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box, 19395-5487, Tehran, 19395-5487, Iran. Electronic address: nabavisf@gmail.com.

Antoni Sureda (A)

Grup de Nutrició Comunitària I Estrès Oxidatiu and CIBEROBN (Physiopathology of Obesity and Nutrition), Universitat de les Illes Balears, Palma de Mallorca, E-07122, Spain. Electronic address: tosugo@hotmail.com.

Akbar Hajizadeh Moghaddam (AH)

Department of Biology, Faculty of Sciences, University of Mazandaran, Babolsar, Iran. Electronic address: a.hajizadeh@umz.ac.irs.

Sedigheh Khanjani (S)

Department of Physiology, Faculty of Biological Sciences, Shahid Behshti University, P.O. Box, 19615-1178, Tehran, 19615-1178, Iran. Electronic address: s.khanjani66@yahoo.com.

Carmen Di Giovanni (C)

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131, Napoli, Italy. Electronic address: carmen.digiovanni@unina.it.

Jianbo Xiao (J)

Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau SAR, China. Electronic address: jianboxiao@yahoo.com.

Samira Shirooie (S)

School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran. Electronic address: shirooie@gmail.com.

Arold Jorel Tsetegho Sokeng (AJ)

Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: aroldjorel.tseteghosokeng01@universitadipavia.it.

Alessandra Baldi (A)

Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: alessandra.baldi.alimenti@gmail.com.

Luisa Mannina (L)

Istituto di Metodologie Chimiche, Laboratorio di Risonanza Magnetica "Annalaura Segre", CNR, 00015, Monterotondo (Rome), Italy; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, P.le Aldo Moro 5, 00185, Rome, Italy. Electronic address: luisa.mannina@uniroma1.it.

Seyed Mohammad Nabavi (SM)

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box, 19395-5487, Tehran, 19395-5487, Iran. Electronic address: nabavi208@gmail.com.

Maria Daglia (M)

Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, Pavia University, Viale Taramelli 12, Pavia 27100, Italy. Electronic address: maria.daglia@unipv.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antidepressive effects of a chemically...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Antidépresseurs › Antidepressive effects of a chemically...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Dépression › Antidepressive effects of a chemically...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Antidepressive effects of a chemically...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Elaeocarpaceae › Antidepressive effects of a chemically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Antidepressive effects of a chemically...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Antidepressive effects of a chemically...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Angiopathies intracrâniennes › Accident vasculaire cérébral › Antidepressive effects of a chemically...