The role of G-quadruplex structures of LIGS-generated aptamers R1.2 and R1.3 in IgM specific recognition.
Aptamers
G-quadruplex
Membrane-bound IgM
Journal
International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
received:
31
01
2019
revised:
17
04
2019
accepted:
18
04
2019
pubmed:
26
4
2019
medline:
20
11
2019
entrez:
26
4
2019
Statut:
ppublish
Résumé
Exploiting a variant of SELEX called "Ligand-Guided Selection" (LI-GS), we recently identified two novel truncated G-rich aptamers, called R1.2 and R1.3, specific for membrane-bound IgM (mIgM), the hallmark of B cells. Herein, the conformational behaviour of these aptamers has been analysed by multiple biophysical methods. In order to investigate their functional secondary structures, these studies have been carried out in pseudo-physiological buffers mimicking different cellular environments. Both aptamers proved to be highly polymorphic, folding into stable, unimolecular G-quadruplex structures in K
Identifiants
pubmed: 31022491
pii: S0141-8130(19)30827-X
doi: 10.1016/j.ijbiomac.2019.04.141
pmc: PMC6548653
mid: NIHMS1528168
pii:
doi:
Substances chimiques
Aptamers, Nucleotide
0
Immunoglobulin M
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-849Subventions
Organisme : NIGMS NIH HHS
ID : SC1 GM122648
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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