The cell in the ink: Improving biofabrication by printing stem cells for skeletal regenerative medicine.
3D printing
Additive manufacturing
Biofabrication
Bioink
Bioprinting
Cell printing
Hydrogels
Journal
Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
26
11
2018
revised:
28
03
2019
accepted:
06
04
2019
pubmed:
26
4
2019
medline:
31
7
2020
entrez:
26
4
2019
Statut:
ppublish
Résumé
Recent advances in regenerative medicine have confirmed the potential to manufacture viable and effective tissue engineering 3D constructs comprising living cells for tissue repair and augmentation. Cell printing has shown promising potential in cell patterning in a number of studies enabling stem cells to be precisely deposited as a blueprint for tissue regeneration guidance. Such manufacturing techniques, however, face a number of challenges including; (i) post-printing cell damage, (ii) proliferation impairment and, (iii) poor or excessive final cell density deposition. The use of hydrogels offers one approach to address these issues given the ability to tune these biomaterials and subsequent application as vectors capable of delivering cell populations and as extrusion pastes. While stem cell-laden hydrogel 3D constructs have been widely established in vitro, clinical relevance, evidenced by in vivo long-term efficacy and clinical application, remains to be demonstrated. This review explores the central features of cell printing, cell-hydrogel properties and cell-biomaterial interactions together with the current advances and challenges in stem cell printing. A key focus is the translational hurdles to clinical application and how in vivo research can reshape and inform cell printing applications for an ageing population.
Identifiants
pubmed: 31022557
pii: S0142-9612(19)30220-0
doi: 10.1016/j.biomaterials.2019.04.009
pmc: PMC6527863
pii:
doi:
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-24Subventions
Organisme : Medical Research Council
ID : MR/R015651/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P017711/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/LO21072/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L00609X
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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