The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function.
alternative lengthening of telomeres
end-protection problem
shelterin complex
telomere damage
telomere maintenance
telomere replication
telomeric double strand breaks
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
24 04 2019
24 04 2019
Historique:
received:
26
03
2019
revised:
13
04
2019
accepted:
18
04
2019
entrez:
27
4
2019
pubmed:
27
4
2019
medline:
27
4
2019
Statut:
epublish
Résumé
Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can sequester the chromosome terminus from DNA-end sensors and inhibition of key steps in the DNA damage response. While blocking the DNA damage response at chromosome ends, telomeres make wide use of many of its players to deal with exogenous damage and replication stress. This review focuses on the interplay between the end-protection functions and the response to DNA damage occurring inside the telomeric repeats, as well as on the consequences that telomere damage has on telomere structure and function.
Identifiants
pubmed: 31022960
pii: genes10040318
doi: 10.3390/genes10040318
pmc: PMC6523756
pii:
doi:
Substances chimiques
Telomere-Binding Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
I have no competing financial interests.
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