Phosphoinositide 3 Kinase Signaling in Human Stem Cells from Reprogramming to Differentiation: A Tale in Cytoplasmic and Nuclear Compartments.

Cell Differentiation Cellular Reprogramming Human Embryonic Stem Cells / cytology Humans Induced Pluripotent Stem Cells / cytology Mesenchymal Stem Cells / cytology Phosphatidylinositol 3-Kinase / metabolism Signal Transduction
inositide signaling nucleus stem cells

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
24 04 2019
Historique:
received: 25 03 2019
revised: 19 04 2019
accepted: 21 04 2019
entrez: 27 4 2019
pubmed: 27 4 2019
medline: 23 8 2019
Statut: epublish

Résumé

Stem cells are undifferentiated cells that can give rise to several different cell types and can self-renew. Given their ability to differentiate into different lineages, stem cells retain huge therapeutic potential for regenerative medicine. Therefore, the understanding of the signaling pathways involved in stem cell pluripotency maintenance and differentiation has a paramount importance in order to understand these biological processes and to develop therapeutic strategies. In this review, we focus on phosphoinositide 3 kinase (PI3K) since its signaling pathway regulates many cellular processes, such as cell growth, proliferation, survival, and cellular transformation. Precisely, in human stem cells, the PI3K cascade is involved in different processes from pluripotency and induced pluripotent stem cell (iPSC) reprogramming to mesenchymal and oral mesenchymal differentiation, through different and interconnected mechanisms.

Identifiants

DOI: 10.3390/ijms20082026 PMID: 31022972 PMC: PMC6514809
pubmed: 31022972
pii: ijms20082026
doi: 10.3390/ijms20082026
pmc: PMC6514809
pii:
doi:

Substances chimiques

Phosphatidylinositol 3-Kinase EC 2.7.1.137

Types de publication

Journal Article Review

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Giulia Ramazzotti (G)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. giulia.ramazzotti@unibo.it.

Stefano Ratti (S)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. stefano.ratti@unibo.it.

Roberta Fiume (R)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. roberta.fiume@unibo.it.

Matilde Yung Follo (MY)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. matilde.follo@unibo.it.

Anna Maria Billi (AM)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. annamaria.billi@unibo.it.

Isabella Rusciano (I)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. isabella.rusciano3@unibo.it.

Eric Owusu Obeng (E)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. eric.owusuobeng2@unibo.it.

Lucia Manzoli (L)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. lucia.manzoli@unibo.it.

Lucio Cocco (L)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. lucio.cocco@unibo.it.

Irene Faenza (I)

Department of Biomedical Sciences, University of Bologna, Via Irnerio, 48, 40126 Bologna, Italy. Irene.faenza2@unibo.it.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires humaines › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol 3-kinase › Phosphoinositide 3 Kinase Signaling in Human...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Phosphoinositide 3 Kinase Signaling in Human...