TPR-containing proteins control protein organization and homeostasis for the endoplasmic reticulum.
Endoplasmic reticulum
TPR domains
chaperones
glycosylation
protein translocation
Journal
Critical reviews in biochemistry and molecular biology
ISSN: 1549-7798
Titre abrégé: Crit Rev Biochem Mol Biol
Pays: England
ID NLM: 8903774
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
27
4
2019
medline:
15
2
2020
entrez:
27
4
2019
Statut:
ppublish
Résumé
The endoplasmic reticulum (ER) is a complex, multifunctional organelle comprised of a continuous membrane and lumen that is organized into a number of functional regions. It plays various roles including protein translocation, folding, quality control, secretion, calcium signaling, and lipid biogenesis. Cellular protein homeostasis is maintained by a complicated chaperone network, and the largest functional family within this network consists of proteins containing tetratricopeptide repeats (TPRs). TPRs are well-studied structural motifs that mediate intermolecular protein-protein interactions, supporting interactions with a wide range of ligands or substrates. Seven TPR-containing proteins have thus far been shown to localize to the ER and control protein organization and homeostasis within this multifunctional organelle. Here, we discuss the roles of these proteins in controlling ER processes and organization. The crucial roles that TPR-containing proteins play in the ER are highlighted by diseases or defects associated with their mutation or disruption.
Identifiants
pubmed: 31023093
doi: 10.1080/10409238.2019.1590305
pmc: PMC6816462
mid: NIHMS1056173
doi:
Substances chimiques
Molecular Chaperones
0
Proteins
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103-118Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM086874
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008515
Pays : United States
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