Identifying the lifetime cognitive and socioeconomic antecedents of cognitive state: seven decades of follow-up in a British birth cohort study.
Adolescent
Adult
Aged
Aging
Apolipoprotein E4
/ metabolism
Child
Child Development
Cognition
Cognition Disorders
/ epidemiology
Cohort Studies
Dementia
/ epidemiology
Educational Status
England
Female
Follow-Up Studies
Health Surveys
Humans
Language Arts
Longitudinal Studies
Male
Memory
Middle Aged
Occupations
Scotland
Social Class
Wales
Wechsler Scales
White People
Young Adult
dementia
epidemiology
old age psychiatry
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
24 04 2019
24 04 2019
Historique:
entrez:
27
4
2019
pubmed:
27
4
2019
medline:
14
4
2020
Statut:
epublish
Résumé
The life course determinants of midlife and later life cognitive function have been studied using longitudinal population-based cohort data, but far less is known about whether the pattern of these pathways is similar or distinct for clinically relevant cognitive state. We investigated this for Addenbrooke's Cognitive Examination third edition (ACE-III), used in clinical settings to screen for cognitive impairment and dementia. Longitudinal birth cohort study. Residential addresses in England, Wales and Scotland. 1762 community-dwelling men and women of European heritage, enrolled since birth in the Medical Research Council (MRC) National Survey of Health and Development (the British 1946 birth cohort). ACE-III. Path modelling estimated direct and indirect associations between apolipoprotein E ( The ACE-III in the general population shows a pattern of life course antecedents that is similar to neuropsychological measures of cognitive function, and may be used to represent normal cognitive ageing as well as a screen for cognitive impairment and dementia.
Identifiants
pubmed: 31023749
pii: bmjopen-2018-024404
doi: 10.1136/bmjopen-2018-024404
pmc: PMC6502022
doi:
Substances chimiques
Apolipoprotein E4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024404Subventions
Organisme : Wellcome Trust
ID : WT107467
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 107467/Z/15/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12019/3
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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