Effects of Different Stressors Are Modulated by Different Neurobiological Systems: The Role of GABA-A Versus CB1 Receptor Gene Variants in Anxiety and Depression.

CNR1 GABA GABRA6 anxiety depression endocannabinoid system gene-environment interaction types of stress

Journal

Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935

Informations de publication

Date de publication:
2019
Historique:
received: 15 01 2019
accepted: 20 03 2019
entrez: 27 4 2019
pubmed: 27 4 2019
medline: 27 4 2019
Statut: epublish

Résumé

Environmental stress and its interaction with genetic variation are key contributors in the development of depression and anxiety, yet there is a failure to identify replicable genetic variants and gene-interaction effects in the background of these psychiatric symptoms. Recently it has been reported that

Identifiants

pubmed: 31024264
doi: 10.3389/fncel.2019.00138
pmc: PMC6467241
doi:

Types de publication

Journal Article

Langues

eng

Pagination

138

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Auteurs

Xenia Gonda (X)

Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.

Peter Petschner (P)

MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Nora Eszlari (N)

NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Sara Sutori (S)

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Zsofia Gal (Z)

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Szabolcs Koncz (S)

Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Ian M Anderson (IM)

Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom.

Bill Deakin (B)

Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom.
Greater Manchester Mental Health NHS Foundation Trust, The University of Manchester, Manchester, United Kingdom.

Gabriella Juhasz (G)

MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.
Neuroscience and Psychiatry Unit, Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biological, Medical and Human Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, United Kingdom.
SE-NAP 2 Genetic Brain Imaging Migraine Research Group, Semmelweis University, Budapest, Hungary.

Gyorgy Bagdy (G)

MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary.
NAP-2-SE New Antidepressant Target Research Group, Hungarian Brain Research Program, Semmelweis University, Budapest, Hungary.
Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Budapest, Hungary.

Classifications MeSH