Metabolic Pathways and Potencies of New Fentanyl Analogs.
fentanyl analogs
fentanyl biotransformations
in vivo and in vitro metabolism
metabolic profile
novel synthetic opioids
receptor binding affinity
toxicity
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2019
2019
Historique:
received:
20
11
2018
accepted:
26
02
2019
entrez:
27
4
2019
pubmed:
27
4
2019
medline:
27
4
2019
Statut:
epublish
Résumé
Up to now, little is known about the metabolic pathways of new fentanyl analogs that have recently emerged on the drug markets worldwide with high potential for producing addiction and severe adverse effects including coma and death. For some of the compounds, limited information on the metabolism has been published, however, for others so far no information is available. Considering the well characterized metabolism of the pharmaceutically used opioid fentanyl and the so far available data, the metabolism of the new fentanyl analogs can be anticipated to generally involve reactions like hydrolysis, hydroxylation (and further oxidation steps),
Identifiants
pubmed: 31024296
doi: 10.3389/fphar.2019.00238
pmc: PMC6461066
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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