Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease.
ADPKD
Histology
Renal denervation
Sympathetic renal hyperactivity
Journal
Journal of nephrology
ISSN: 1724-6059
Titre abrégé: J Nephrol
Pays: Italy
ID NLM: 9012268
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
24
02
2019
accepted:
13
04
2019
pubmed:
27
4
2019
medline:
8
6
2021
entrez:
27
4
2019
Statut:
ppublish
Résumé
Several evidences support the hypothesis that patients affected by autosomal dominant polycystic kidney disease (ASPKD) show a sympathetic renal hyperactivity. Nevertheless, no morphological evidences are available yet. Therefore, the aim of the study was to demonstrate that an increase in sympathetic renal artery innervation was present in the ADPKD patients by using histological methods. In addition, here we correlated the sympathetic renal artery innervation with the evolutionary state of ADPKD (increase in volume of kidney, onset of chronic renal failure and hypertension). To this end, peri-adventitial innervation of renal arteries was studied using morphological methods from 49 patients in total: 29 underwent surgical nephrectomies for ADPKD and 20 non-dialysis patients (CTRL group) undergoing nephrectomy for other diseases. Nerve density (number of nerves per mm
Identifiants
pubmed: 31025246
doi: 10.1007/s40620-019-00612-3
pii: 10.1007/s40620-019-00612-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-89Références
J Am Soc Nephrol. 2009 Sep;20(9):1888-93
pubmed: 19696226
Lancet. 2015 May 16;385(9981):1993-2002
pubmed: 26090645
Am J Kidney Dis. 2014 Jun;63(6):1019-21
pubmed: 24518126
Nephrol Dial Transplant. 2017 Jun 1;32(6):1053-1060
pubmed: 28498963
Int J Cardiol. 2013 Jan 20;162(3):e58-9
pubmed: 22721643
J Pharmacol Exp Ther. 2008 Jun;325(3):751-7
pubmed: 18364471
N Engl J Med. 1992 Dec 31;327(27):1912-8
pubmed: 1454086
Curr Opin Nephrol Hypertens. 2012 Jan;21(1):46-51
pubmed: 22080859
Trans Assoc Am Physicians. 1989;102:158-62
pubmed: 2561639
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R937-46
pubmed: 10749782
Hypertension. 2011 Apr;57(4):846-51
pubmed: 21300663
Intern Med J. 2016 Aug;46(8):883-92
pubmed: 27553994
Kidney Int. 2015 Jul;88(1):17-27
pubmed: 25786098
JACC Cardiovasc Interv. 2014 Oct;7(10):1184-93
pubmed: 25240550
Nat Med. 2003 Oct;9(10):1323-6
pubmed: 14502283
Am J Kidney Dis. 2012 Jun;59(6):858-61
pubmed: 22361041
Semin Dial. 2013 May-Jun;26(3):333-43
pubmed: 23627490
N Engl J Med. 2014 Dec 11;371(24):2267-76
pubmed: 25399731
J Nephrol. 2019 Feb;32(1):83-91
pubmed: 30022320
J Am Heart Assoc. 2015 Nov 26;4(12):null
pubmed: 26611731
Kidney Int. 2003 Feb;63(2):678-85
pubmed: 12631134
Clin Res Cardiol. 2014 Mar;103(3):251-3
pubmed: 24322784
J Am Soc Nephrol. 2001 Nov;12(11):2427-33
pubmed: 11675419
Circulation. 2002 Jan 22;105(3):297-303
pubmed: 11804983
N Engl J Med. 2012 Dec 20;367(25):2407-18
pubmed: 23121377
Hypertension. 2011 Apr;57(4):683-5
pubmed: 21300664