Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype.
ACTH
baboon
catch-up growth
cortisol
developmental programing
high-fat diet
maternal nutrition
mismatch
non-human primates
undernutrition
Journal
Journal of medical primatology
ISSN: 1600-0684
Titre abrégé: J Med Primatol
Pays: Denmark
ID NLM: 0320626
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
21
11
2018
revised:
26
02
2019
accepted:
25
03
2019
pubmed:
27
4
2019
medline:
2
5
2020
entrez:
27
4
2019
Statut:
ppublish
Résumé
Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months. Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation. Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups. Mismatch produces sexually dimorphic post-natal growth phenotypes.
Sections du résumé
BACKGROUND
Non-human primate models of developmental programing by maternal mismatch between pregnancy and lactation diets are needed for translation to human programing outcomes. We present baboon offspring morphometry from birth to 3 years, and blood cortisol and adrenocorticotropin (ACTH) from 2 to 24 months.
METHODS
Control mothers ate chow; mismatch mothers ate 30% less than controls during pregnancy and high-fat high-energy diet through lactation.
RESULTS
Mismatch mothers lost weight during pregnancy. At birth, there were trends toward lower weight in mismatch offspring of both sexes (P = 0.06). From 0-3 years, catch-up growth occurred. Mismatch offspring male and female body weight increased faster than controls (P < 0.001). Mismatch female offspring showed greater increase in BMI (P < 0.001) and abdominal circumference (P = 0.008) vs controls. ACTH and cortisol slopes from 2 to 24 months of age were similar between groups in both sexes. Cortisol and ACTH increased after weaning in all groups.
CONCLUSIONS
Mismatch produces sexually dimorphic post-natal growth phenotypes.
Identifiants
pubmed: 31025367
doi: 10.1111/jmp.12415
pmc: PMC6610582
mid: NIHMS1021168
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-235Subventions
Organisme : NIA NIH HHS
ID : U19 AG057758
Pays : United States
Organisme : NICHD NIH HHS
ID : P01 HD021350
Pays : United States
Organisme : NCRR NIH HHS
ID : R24 RR031459
Pays : United States
Organisme : NIH HHS
ID : P51 OD011133
Pays : United States
Organisme : NIH HHS
ID : R24 OD011183
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Reprod Fertil Dev. 1994;6(2):141-50
pubmed: 7991781
BMJ. 1999 Feb 13;318(7181):427-31
pubmed: 9974455
Semin Perinatol. 2008 Jun;32(3):140-7
pubmed: 18482612
J Physiol. 2018 Dec;596(23):5777-5790
pubmed: 29098705
FASEB J. 2014 May;28(5):2191-201
pubmed: 24481968
Physiology (Bethesda). 2006 Feb;21:29-37
pubmed: 16443820
Br J Nutr. 2014 Feb;111(4):616-24
pubmed: 24124655
J Dev Orig Health Dis. 2018 Apr;9(2):137-142
pubmed: 29017630
J Pediatr. 2015 Mar;166(3):666-71.e1
pubmed: 25722270
Front Aging Neurosci. 2017 Apr 11;9:92
pubmed: 28443017
Horm Res Paediatr. 2013;79(2):103-9
pubmed: 23466642
Am J Clin Nutr. 2013 Aug;98(2):396-402
pubmed: 23783297
Circulation. 2002 Mar 5;105(9):1088-92
pubmed: 11877360
Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9591-5
pubmed: 12082185
Ageing Res Rev. 2017 Oct;39:96-105
pubmed: 27594376
Am Fam Physician. 1998 Aug;58(2):453-60, 466-7
pubmed: 9713399
Br Med Bull. 2001;60:5-20
pubmed: 11809615
Lancet. 1998 Jan 17;351(9097):173-7
pubmed: 9449872
J Physiol. 2017 Jul 1;595(13):4245-4260
pubmed: 28439937
J Med Primatol. 2004 Jun;33(3):117-26
pubmed: 15102068
FEBS Lett. 1999 Apr 1;448(1):4-8
pubmed: 10217398
Methods Mol Biol. 2018;1735:167-199
pubmed: 29380312
Age (Dordr). 2015 Jun;37(3):9774
pubmed: 25953670
J Physiol. 2010 Apr 15;588(Pt 8):1349-59
pubmed: 20176628
Nature. 2004 Jul 22;430(6998):419-21
pubmed: 15269759
Endocrinology. 2013 Jul;154(7):2365-73
pubmed: 23625543
Gerontology. 2018;64(3):237-245
pubmed: 29324453
Anim Behav. 2014 Nov 1;97:241-247
pubmed: 25431499
Am J Clin Nutr. 2016 Feb;103(2):579-88
pubmed: 26718412
J Matern Fetal Neonatal Med. 2006 Sep;19(9):557-62
pubmed: 16966124
Diabetologia. 1998 Oct;41(10):1163-7
pubmed: 9794102
Diabetologia. 2004 Jun;47(6):1064-70
pubmed: 15156313
Reprod Sci. 2012 May;19(5):493-504
pubmed: 22344725
Endocrinology. 2015 Oct;156(10):3528-37
pubmed: 26214037
J Physiol. 2018 Oct;596(19):4611-4628
pubmed: 29972240
Nature. 2004 Jan 29;427(6973):411-2
pubmed: 14749819
Placenta. 2007 Nov-Dec;28(11-12):1200-10
pubmed: 17707905
Physiol Rep. 2015 Nov;3(11):
pubmed: 26537341
J Physiol. 2018 Nov;596(21):5083-5098
pubmed: 30144074
J Med Primatol. 2017 Dec;46(6):293-303
pubmed: 28744866
Int J Obes (Lond). 2018 Jun;42(5):1092-1096
pubmed: 29463919
J Med Primatol. 2015 Jun;44(3):143-57
pubmed: 25891005
Obesity (Silver Spring). 2006 Aug;14(8):1330-43
pubmed: 16988075
J Physiol. 2017 Feb 15;595(4):1093-1110
pubmed: 27988927