Distribution and Short-term Prognostic Value of the 21-gene recurrence score in African American compared to White American breast cancer patients.
Oncotype DX
breast cancer
disparities
Journal
The breast journal
ISSN: 1524-4741
Titre abrégé: Breast J
Pays: United States
ID NLM: 9505539
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
17
08
2018
revised:
22
08
2018
accepted:
23
08
2018
pubmed:
27
4
2019
medline:
14
1
2020
entrez:
27
4
2019
Statut:
ppublish
Résumé
We evaluated 328 patients (34.8% African American [AA]; 65.2% White American [WA]) with hormone receptor-positive, HER2/neu-negative breast cancer. Mean age (60 years); mean tumor size (1.6 and 1.7 cm for AA and WA, respectively) were similar, and mean BMI was higher for AA (33 vs 29.8; P = 0.001). Recurrence score (RS) distribution was similar- 8.3% AA and 5.9% WA with high RS (≥31). No significant differences were observed in delivery of chemotherapy stratified by score. With median follow-up 27.2 months for AA and 33.4 months for WA, distant recurrence occurred in 1.0% and 1.6%, respectively (P = 1). Our results suggest comparable RS utility in AA and WA patients.
Substances chimiques
ERBB2 protein, human
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
667-671Informations de copyright
© 2019 Wiley Periodicals, Inc.