Therapeutic targeting of gastrointestinal cancer stem cells.
cancer stem cells
chemoresistance
gastrointestinal cancer
immunotherapy
radioresistance
targeted therapies
Journal
Regenerative medicine
ISSN: 1746-076X
Titre abrégé: Regen Med
Pays: England
ID NLM: 101278116
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
pubmed:
27
4
2019
medline:
4
4
2020
entrez:
27
4
2019
Statut:
ppublish
Résumé
Gastrointestinal cancers remain a tremendous burden on society. Despite advances in therapy options, including chemotherapy and radiation, cancer mortality from recurrences and metastases occur frequently. Cancer stem cells (CSCs) drive disease recurrence and metastasis, as these cells are uniquely equipped to self-renew and evade therapy. Therefore, cancer eradication requires treatment strategies that target CSCs in addition to differentiated cancer cells. This review highlights current literature on therapies targeting CSCs in gastrointestinal cancer.
Identifiants
pubmed: 31025613
doi: 10.2217/rme-2018-0146
pmc: PMC6886570
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-343Subventions
Organisme : NCI NIH HHS
ID : P30 CA056036
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204481
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206026
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008562
Pays : United States
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