Decarboxylative Fluorination of 2-Pyridylacetates.
decarboxylation
difluoromethyl group
fluorination
methyl ester
pyridine
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
04 Jun 2019
04 Jun 2019
Historique:
received:
05
02
2019
revised:
01
04
2019
pubmed:
27
4
2019
medline:
27
4
2019
entrez:
27
4
2019
Statut:
ppublish
Résumé
Syntheses of substituted pyridines and fluorinated compounds, which are often pharmaceutical targets, are important objectives in organic chemistry. Herein, we found that decarboxylative fluorination of lithium 2-pyridylacetates occur under catalyst-free conditions. The phenomenon can be applied to one-pot transformation of substituted methyl 2-pyridylacetate to 2-(fluoroalkyl)pyridine by decarboxylative fluorination of the intermediate lithium 2-pyridylacetate. This method was also applied to the syntheses of 2-(difluoroalkyl)pyridines.
Identifiants
pubmed: 31026095
doi: 10.1002/chem.201900565
doi:
Types de publication
Journal Article
Langues
eng
Pagination
7453-7456Subventions
Organisme : Japan Society for the Promotion of Science
ID : 18H01974
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.