New criteria for multiple chemical sensitivity based on the Quick Environmental Exposure and Sensitivity Inventory developed in response to rapid changes in ongoing chemical exposures among Japanese.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
10
2018
accepted:
27
03
2019
entrez:
27
4
2019
pubmed:
27
4
2019
medline:
31
12
2019
Statut:
epublish
Résumé
The Quick Environmental Exposure and Sensitivity Inventory (QEESI) developed by Miller and Prihoda in the USA is used as a questionnaire for patients with multiple chemical sensitivity (MCS) in >10 countries. We developed a Japanese version of QEESI, assessed its reliability and validity, and defined original cut-off values for screening Japanese patients with MCS in 2003. Our recent study revealed that opportunities for exposure to various chemicals had increased for people in Japan, while subjective symptoms of MCS in patients had increased in severity. In this study, we considered new cut-off values that combined QEESI subscale scores based on the current situation in Japan. The questionnaire used was a Japanese version of QEESI. The survey was conducted from 2012 to 2015. Participants were 111 patients with MCS (mean age: 46 ± 20, 81% female) initially diagnosed by physicians, and 444 age- and gender-matched controls not diagnosed with MCS by doctors. The discriminatory validity of QEESI scores of patients and controls were evaluated by logistic regression and receiver operating characteristic analyses when considering interactions of the Masking Index (ongoing chemical exposure). New combined cut-off values were then set. New combined cut-off values (meeting conditions of Chemical Intolerances ≥ 30, Symptom Severity ≥ 13, and Life Impacts ≥ 17) showed high sensitivity (82.0%) and specificity (94.4%). Using new criteria when considering ongoing chemical exposure, study participants were categorized as: Very suggestive, Somewhat suggestive, Problematic, and Not suggestive. Participants classified as Very suggestive included 25 (5.6%) controls. We have set new criteria with combined cut-off values based on current Japanese conditions. Such new criteria can be used for screening and as a diagnostic aid for Japanese patients with MCS and suggest approximately 6% of the Japanese general population may be classified as "Very suggestive people with MCS".
Sections du résumé
BACKGROUND & OBJECTIVES
The Quick Environmental Exposure and Sensitivity Inventory (QEESI) developed by Miller and Prihoda in the USA is used as a questionnaire for patients with multiple chemical sensitivity (MCS) in >10 countries. We developed a Japanese version of QEESI, assessed its reliability and validity, and defined original cut-off values for screening Japanese patients with MCS in 2003. Our recent study revealed that opportunities for exposure to various chemicals had increased for people in Japan, while subjective symptoms of MCS in patients had increased in severity. In this study, we considered new cut-off values that combined QEESI subscale scores based on the current situation in Japan.
METHODS
The questionnaire used was a Japanese version of QEESI. The survey was conducted from 2012 to 2015. Participants were 111 patients with MCS (mean age: 46 ± 20, 81% female) initially diagnosed by physicians, and 444 age- and gender-matched controls not diagnosed with MCS by doctors. The discriminatory validity of QEESI scores of patients and controls were evaluated by logistic regression and receiver operating characteristic analyses when considering interactions of the Masking Index (ongoing chemical exposure). New combined cut-off values were then set.
RESULTS
New combined cut-off values (meeting conditions of Chemical Intolerances ≥ 30, Symptom Severity ≥ 13, and Life Impacts ≥ 17) showed high sensitivity (82.0%) and specificity (94.4%). Using new criteria when considering ongoing chemical exposure, study participants were categorized as: Very suggestive, Somewhat suggestive, Problematic, and Not suggestive. Participants classified as Very suggestive included 25 (5.6%) controls.
CONCLUSIONS
We have set new criteria with combined cut-off values based on current Japanese conditions. Such new criteria can be used for screening and as a diagnostic aid for Japanese patients with MCS and suggest approximately 6% of the Japanese general population may be classified as "Very suggestive people with MCS".
Identifiants
pubmed: 31026284
doi: 10.1371/journal.pone.0215144
pii: PONE-D-18-30486
pmc: PMC6485617
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0215144Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Hyg Environ Health. 2018 Sep;221(8):1085-1096
pubmed: 30115513
J Occup Environ Med. 2018 Mar;60(3):e152-e156
pubmed: 29329146
Int Arch Occup Environ Health. 2005 Aug;78(7):559-64
pubmed: 16001204
Am J Epidemiol. 1999 Jul 1;150(1):1-12
pubmed: 10400546
Arch Environ Health. 1999 May-Jun;54(3):147-9
pubmed: 10444033
Tohoku J Exp Med. 2002 Nov;198(3):163-73
pubmed: 12597243
Toxicol Ind Health. 2009 Feb;25(1):71-8
pubmed: 19318506
Psychosom Med. 2005 Mar-Apr;67(2):318-25
pubmed: 15784800
Environ Health Prev Med. 2009 Sep;14(5):267-75
pubmed: 19603254
J Environ Public Health. 2012;2012:304314
pubmed: 22529872
Med Clin (Barc). 2013 Apr 15;140(7):302-4
pubmed: 23347502
J Psychosom Res. 2017 Aug;99:40-44
pubmed: 28712429
Int J Hyg Environ Health. 2008 Oct;211(5-6):682-9
pubmed: 18155642
J Allergy Clin Immunol. 1997 Apr;99(4):570-4
pubmed: 9111504
Environ Health Prev Med. 2014 May;19(3):215-9
pubmed: 24477857
Nihon Eiseigaku Zasshi. 2018;73(1):1-8
pubmed: 29386440
Environ Health Perspect. 2003 Sep;111(12):1490-7
pubmed: 12948889
Int Arch Occup Environ Health. 2008 Jul;81(7):881-7
pubmed: 18058120
Toxicol Ind Health. 2003 Jul;19(2-6):41-9
pubmed: 15697173
Int J Environ Res Public Health. 2015 Oct 05;12(10):12446-65
pubmed: 26445055
Arch Environ Occup Health. 2015;70(6):341-53
pubmed: 25137616
Tohoku J Exp Med. 2001 Feb;193(2):115-26
pubmed: 11318027
Arch Environ Health. 1996 Jul-Aug;51(4):275-82
pubmed: 8757407
Arch Environ Health. 1993 Jan-Feb;48(1):19-26
pubmed: 8452395
Ann Allergy. 1965 Jan;23:7-22
pubmed: 14251998
J Occup Environ Med. 2009 Jul;51(7):838-47
pubmed: 19542897
Public Health. 2005 Jul;119(7):568-77
pubmed: 15925670
Toxicol Ind Health. 1999 Apr-Jun;15(3-4):370-85
pubmed: 10416289
Environ Health Prev Med. 2015 Mar;20(2):123-9
pubmed: 25500796
J Occup Environ Med. 2005 May;47(5):518-22
pubmed: 15891531
Occup Med. 1987 Oct-Dec;2(4):655-61
pubmed: 3313760
Oxid Med Cell Longev. 2013;2013:351457
pubmed: 23844274
Environ Health Perspect. 1997 Mar;105 Suppl 2:445-53
pubmed: 9167978
Int Arch Occup Environ Health. 2010 Jan;83(1):95-104
pubmed: 19468745
Allergy Asthma Immunol Res. 2014 Sep;6(5):409-14
pubmed: 25228997
Toxicol Ind Health. 1999 Apr-Jun;15(3-4):386-97
pubmed: 10416290
Am J Public Health. 2004 May;94(5):746-7
pubmed: 15117694
Int J Hyg Environ Health. 2005;208(4):271-8
pubmed: 16078641