Changing clinical and molecular characteristics of hepatitis E virus infection in Mie Prefecture, Japan: Disappearance of indigenous subtype 3e strains.
Japan
Mie prefecture
disappearance
hepatitis E virus
indigenous strain
phylogenetic analyses
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
ISSN: 1386-6346
Titre abrégé: Hepatol Res
Pays: Netherlands
ID NLM: 9711801
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
24
02
2019
revised:
09
04
2019
accepted:
19
04
2019
pubmed:
27
4
2019
medline:
27
4
2019
entrez:
27
4
2019
Statut:
ppublish
Résumé
To evaluate the clinical and molecular characteristics of hepatitis E virus (HEV) infection in Mie Prefecture, Japan, from 2004 through 2018. The clinical information of hepatitis E cases was collected from 21 medical institutions in Mie Prefecture. The nucleotide sequences of infecting HEV strains were determined for cases with available serum samples. The origins or transmission routes were inferred from phylogenetic analyses of the nucleotide sequences. Fifty-three patients were diagnosed with HEV infection. The number of cases increased each year through 2012 and then decreased. Analyses of the clinical characteristics of the cases indicated that even mild cases were detected in the latter 10 years of the study. Nucleotide sequence analyses were undertaken on 38 of the 53 cases. The HEV subtype 3e (HEV-3e) strains identified for 13 cases were closely related to a swine HEV-3e strain that was isolated from the liver of a pig bred in Mie Prefecture. The number of cases infected with the indigenous Mie HEV-3e strains increased until 2012 but have not been reported since 2014. In the latter half of the study, cases involving various HEV strains of different genotypes and subtypes emerged. The disappearance of indigenous Mie HEV-3e strains appeared to be the primary cause for the decrease in hepatitis E cases in Mie Prefecture. The disappearance might have been associated with improved hygienic conditions on pig farms or the closure of contaminated farms. The results suggest that indigenous HEV strains can be eradicated by appropriate management.
Types de publication
Journal Article
Langues
eng
Pagination
1003-1014Subventions
Organisme : Fujita Health University
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0210043
Organisme : Ministry of Education, Culture, Sports, Science and Technology of Japan
Organisme : Ministry of Health, Labor and Welfare of Japan
Informations de copyright
© 2019 The Japan Society of Hepatology.
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