Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients.
gene expression
head and neck cancer
hypoxia
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Apr 2019
25 Apr 2019
Historique:
received:
06
03
2019
revised:
11
04
2019
accepted:
19
04
2019
entrez:
28
4
2019
pubmed:
28
4
2019
medline:
28
4
2019
Statut:
epublish
Résumé
Hypoxic head and neck tumors respond poorly to radiotherapy and can be identified using gene expression profiles. However, it is unknown whether treatment outcome is driven by acute or chronic hypoxia. Gene expression data of 398 head and neck cancers was collected. Four clinical hypoxia profiles were compared to in vitro acute and chronic hypoxia profiles. Chronic and acute hypoxia profiles were tested for their association to outcome using Cox proportional hazard analyses. In an initial set of 224 patients, scores of the four clinical hypoxia profiles correlated with each other and with chronic hypoxia. However, the acute hypoxia profile showed a stronger association with local recurrence after chemoradiotherapy (
Identifiants
pubmed: 31027242
pii: cancers11040583
doi: 10.3390/cancers11040583
pmc: PMC6520712
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : KWF Kankerbestrijding
ID : A6C7072
Organisme : Seventh Framework Programme
ID : 257144
Organisme : Brunel
ID : -
Organisme : Verwelius
ID : -
Références
Strahlenther Onkol. 2012 Jul;188(7):606-15
pubmed: 22695745
Nat Rev Cancer. 2008 Mar;8(3):180-92
pubmed: 18273037
Lancet Oncol. 2011 Apr;12(4):353-60
pubmed: 21454129
Br J Radiol. 1979 Aug;52(620):650-6
pubmed: 486895
Cancer Res. 2010 Feb 1;70(3):925-35
pubmed: 20103649
BMC Cancer. 2011 May 12;11:167
pubmed: 21569415
Int J Cancer. 2010 Dec 15;127(12):2893-917
pubmed: 21351269
Cancer Res. 2007 Apr 1;67(7):3441-9
pubmed: 17409455
Radiother Oncol. 2010 Jun;95(3):365-70
pubmed: 20346528
Nat Rev Genet. 2009 Dec;10(12):821-32
pubmed: 19884889
Clin Cancer Res. 2016 Jun 1;22(11):2639-49
pubmed: 26755529
J Magn Reson Imaging. 2016 Jul;44(1):72-80
pubmed: 26800280
Int J Radiat Oncol Biol Phys. 2002 Dec 1;54(5):1537-49
pubmed: 12459383
Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):965-8
pubmed: 21683887
Head Neck. 2005 Jul;27(7):622-38
pubmed: 15952198
Br J Cancer. 2010 Jan 19;102(2):428-35
pubmed: 20087356
Int J Radiat Oncol Biol Phys. 1997 May 1;38(2):285-9
pubmed: 9226314
Radiother Oncol. 2016 Feb;118(2):350-8
pubmed: 26711490
Cancer Res. 2002 Dec 1;62(23):7066-74
pubmed: 12460928
Br J Radiol. 1953 Dec;26(312):638-48
pubmed: 13106296
Cancer. 2001 Sep 15;92(6):1484-94
pubmed: 11745226
Cancer Res. 2006 Feb 15;66(4):2361-6
pubmed: 16489042
J Clin Oncol. 2006 Feb 10;24(5):727-35
pubmed: 16418497
Clin Cancer Res. 2013 Sep 1;19(17):4879-88
pubmed: 23820108
Radiother Oncol. 2007 Jun;83(3):374-82
pubmed: 17532074
Radiother Oncol. 2020 Jun;147:186-194
pubmed: 32413532
J Clin Epidemiol. 2002 Jun;55(6):533-44
pubmed: 12063095
Radiother Oncol. 2011 Jul;100(1):22-32
pubmed: 21511351
BMC Bioinformatics. 2013 Jan 16;14:7
pubmed: 23323831
Cancer Res. 2011 Sep 1;71(17):5923-31
pubmed: 21846821
Radiother Oncol. 2000 Oct;57(1):39-43
pubmed: 11033187
J Radiat Res. 2013 Jul;54 Suppl 1:i13-22
pubmed: 23824117
Clin Oncol (R Coll Radiol). 2014 Jun;26(6):344-7
pubmed: 24685344
Clin Cancer Res. 2015 Dec 15;21(24):5630-8
pubmed: 26265694
Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):1192-202
pubmed: 12128120
Cancer. 2006 Aug 15;107(4):757-66
pubmed: 16826581
Strahlenther Onkol. 2012 Jul;188(7):616-27
pubmed: 22454045
Cancer Res. 2008 Jan 15;68(2):605-14
pubmed: 18199558
Radiother Oncol. 1996 Oct;41(1):31-9
pubmed: 8961365
Radiother Oncol. 2013 Sep;108(3):517-22
pubmed: 23719582
Clin Cancer Res. 2010 Nov 1;16(21):5329-38
pubmed: 20837694
Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):161-9
pubmed: 18722267
Br J Cancer. 2015 Jan 20;112(2):238-50
pubmed: 25514380
Radiother Oncol. 2005 Oct;77(1):18-24
pubmed: 16098619
Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1544-52
pubmed: 17931799
Br J Cancer. 2000 Sep;83(5):674-83
pubmed: 10944611
Head Neck. 2009 Jan;31(1):1-8
pubmed: 19031408