Deletions of Chromosome 7q Affect Nuclear Organization and
HLXB9 gene
MNX1 gene
chromosome 7
chromosome deletion
genome organization
leukemia
radial positioning
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Apr 2019
25 Apr 2019
Historique:
received:
12
03
2019
revised:
03
04
2019
accepted:
19
04
2019
entrez:
28
4
2019
pubmed:
28
4
2019
medline:
28
4
2019
Statut:
epublish
Résumé
The radial spatial positioning of individual gene loci within interphase nuclei has been associated with up- and downregulation of their expression. In cancer, the genome organization may become disturbed due to chromosomal abnormalities, such as translocations or deletions, resulting in the repositioning of genes and alteration of gene expression with oncogenic consequences. In this study, we analyzed the nuclear repositioning of
Identifiants
pubmed: 31027247
pii: cancers11040585
doi: 10.3390/cancers11040585
pmc: PMC6521283
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Kidscan Children's Cancer Research
ID : N/A
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