The Influence of Haemostatic Dressing Prototypes for the Emergency Services on the Histopathological Parameters of Porcine Muscle.
Haemostasis
muscles
pigs
wound
Journal
In vivo (Athens, Greece)
ISSN: 1791-7549
Titre abrégé: In Vivo
Pays: Greece
ID NLM: 8806809
Informations de publication
Date de publication:
Historique:
received:
01
02
2019
revised:
01
03
2019
accepted:
07
03
2019
entrez:
28
4
2019
pubmed:
28
4
2019
medline:
21
8
2019
Statut:
ppublish
Résumé
Haemostatic dressings for the uniformed and rescue services are an integral part of life-saving equipment for controlling post-traumatic haemorrhage. The aim of this study was to assess the influence of active constituent substances and materials of haemostatic dressings on muscle tissue and muscle regeneration after traumatic injury. Three hemostatic dressing prototypes were analysed: OBR/G/S sponge: dressing material sponge made of Na-Ca chitosan/algal composite microfibers and nanofibers; OBR/MBT/S: tactic gauze modified with a polymer mixture of Na-Ca chitosan/algal composite microfibers and nanofibers, impregnated with a moderate amount of procoagulants (22.9 g/m Histopathological analysis of muscle tissues from the experimental pigs revealed that the application of modified seton (OBR/MS/S) produced the most satisfactory results. The observed changes were similar on all dates that samples were collected and in all experimental groups, and minor differences in their extent were observed between groups. Regenerative processes were most advanced, and retrograde changes were least apparent in animals treated with OBR/MS/S. Modified seton (OBR/MS/S) induced the least tissue reaction and was most effective in promoting tissue regeneration after injury.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Haemostatic dressings for the uniformed and rescue services are an integral part of life-saving equipment for controlling post-traumatic haemorrhage. The aim of this study was to assess the influence of active constituent substances and materials of haemostatic dressings on muscle tissue and muscle regeneration after traumatic injury.
MATERIALS AND METHODS
METHODS
Three hemostatic dressing prototypes were analysed: OBR/G/S sponge: dressing material sponge made of Na-Ca chitosan/algal composite microfibers and nanofibers; OBR/MBT/S: tactic gauze modified with a polymer mixture of Na-Ca chitosan/algal composite microfibers and nanofibers, impregnated with a moderate amount of procoagulants (22.9 g/m
RESULTS
RESULTS
Histopathological analysis of muscle tissues from the experimental pigs revealed that the application of modified seton (OBR/MS/S) produced the most satisfactory results. The observed changes were similar on all dates that samples were collected and in all experimental groups, and minor differences in their extent were observed between groups. Regenerative processes were most advanced, and retrograde changes were least apparent in animals treated with OBR/MS/S.
CONCLUSION
CONCLUSIONS
Modified seton (OBR/MS/S) induced the least tissue reaction and was most effective in promoting tissue regeneration after injury.
Identifiants
pubmed: 31028189
pii: 33/3/723
doi: 10.21873/invivo.11531
pmc: PMC6559884
doi:
Substances chimiques
Hemostatics
0
Types de publication
Journal Article
Langues
eng
Pagination
723-729Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Références
Science. 2005 Sep 23;309(5743):2064-7
pubmed: 16141372
Mil Med. 2005 Jan;170(1):63-9
pubmed: 15724857
Int J Clin Exp Med. 2015 Jan 15;8(1):10-9
pubmed: 25784969
AANA J. 2013 Dec;81(6):453-8
pubmed: 24597007
J Trauma. 2011 Jul;71(1 Suppl):S4-8
pubmed: 21795876
Am J Sports Med. 1987 Jan-Feb;15(1):9-14
pubmed: 3812867
J Trauma. 2004 Aug;57(2):224-30
pubmed: 15345965
J Trauma. 2009 Oct;67(4):848-55
pubmed: 19820595
Acta Vet Scand. 2017 May 12;59(1):29
pubmed: 28499437
Acta Pharmacol Sin. 2013 Mar;34(3):367-72
pubmed: 23334236
J Trauma. 2010 Feb;68(2):269-78
pubmed: 20154537
Pol J Vet Sci. 2016 Sep 1;19(3):503-507
pubmed: 27760028
Pol J Vet Sci. 2014;17(3):519-21
pubmed: 25286664